Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas
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Otros documentos de la autoría: Sanchis-Segura, Carla; Wilcox, Rand R.; Cruz Gómez, Álvaro Javier; Félix Esbrí, Sonia; Sebastián Tirado, Alba; Forn, Cristina
Metadatos
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comunitat-uji-handle2:10234/8033
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INVESTIGACIONMetadatos
Título
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areasAutoría
Fecha de publicación
2023Editor
BMCISSN
2042-6410Cita bibliográfica
Sanchis-Segura, C., Wilcox, R.R., Cruz-Gómez, A.J., Félix-Esbrí, S., Sebastián-Tirado, A., Forn, C. Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas. Biol Sex Differ 14, 90 (2023). https://doi.org/10.1186/s13293-023-00575-yTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
, MultivariateVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background:
Sex differences in language-related abilities have been reported. It is generally assumed that these differences stem from a different organization of language in the brains of females and males. However, ... [+]
Background:
Sex differences in language-related abilities have been reported. It is generally assumed that these differences stem from a different organization of language in the brains of females and males. However, research in this area has been relatively scarce, methodologically heterogeneous and has yielded conflicting results.
Methods:
Univariate and multivariate sex differences and similarities in gray matter volume (GMVOL) within 18 essential language-processing brain areas were assessed in a sex-balanced sample (N = 588) of right-handed young adults. Univariate analyses involved location, spread, and shape comparisons of the females’ and males’ distributions and were conducted with several robust statistical methods able to quantify the size of sex differences and similarities in a complementary way. Multivariate sex differences and similarities were estimated by the same methods in the continuous scores provided by two distinct multivariate procedures (logistic regression and a multivariate analog of the Wilcoxon–Mann–Whitney test). Additional analyses were addressed to compare the outcomes of these two multivariate analytical strategies and described their structure (that is, the relative contribution of each brain area to the multivariate effects).
Results:
When not adjusted for total intracranial volume (TIV) variation, “large” univariate sex differences (males > females) were found in all 18 brain areas considered. In contrast, “small” differences (females > males) in just two of these brain areas were found when controlling for TIV. The two multivariate methods tested provided very similar results. Multivariate sex differences surpassed univariate differences, yielding "large" differences indicative of larger volumes in males when calculated from raw GMVOL estimates. Conversely, when calculated from TIV-adjusted GMVOL, multivariate differences were "medium" and indicative of larger volumes in females. Despite their distinct size and direction, multivariate sex differences in raw and TIV-adjusted GMVOL shared a similar structure and allowed us to identify the components of the SENT_CORE network which more likely contribute to the observed effects.
Conclusions:
Our results confirm and extend previous findings about univariate sex differences in language-processing areas, offering unprecedented evidence at the multivariate level. We also observed that the size and direction of these differences vary quite substantially depending on whether they are estimated from raw or TIV-adjusted GMVOL measurements. [-]
Publicado en
Biology of sex Differences, 2023, vol. 14Entidad financiadora
Ministerio de Ciencia, Innovación y Universidades | Universitat Jaume I
Identificador de la entidad financiadora
http://dx.doi.org/10.13039/501100011033
Código del proyecto o subvención
MICIU/ICTI2017-2020/PID2019–106793RB-I00 | UJI B2020–02 | PREDOC/2020/22
Título del proyecto o subvención
Neurorehabilitación y recuperación funcional en la esclerosis multiple (EM): evaluación de dos estrategias terapéuticas mediante resonancia magnética funcional
Derechos de acceso
info:eu-repo/semantics/openAccess
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