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Tetrazole derivatives as potent immunomodulatory agents in tumor microenvironment
dc.contributor.author | Pla López, Alberto | |
dc.contributor.author | Carda, Miguel | |
dc.contributor.author | Falomir, Eva | |
dc.date.accessioned | 2024-01-11T07:36:22Z | |
dc.date.available | 2024-01-11T07:36:22Z | |
dc.date.issued | 2023-11-01 | |
dc.identifier.citation | Alberto Pla-López, Miguel Carda, Eva Falomir, Tetrazole derivatives as potent immunomodulatory agents in tumor microenvironment, Biomedicine & Pharmacotherapy, Volume 169, 2023, 115668, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2023.115668. | ca_CA |
dc.identifier.issn | 0753-3322 | |
dc.identifier.uri | http://hdl.handle.net/10234/205399 | |
dc.description.abstract | Twenty-seven compounds bearing a tetrazole ring as a central unit have been designed, synthetized and biologically evaluated. Studies have been performed in order to compare the effect of tetrazole derivatives bearing amine electron-donor or nitro electron-acceptor groups. The antiproliferative activity has been determined in monoculture studies on tumor cell lines HT-29, A-549, MCF-7 and on non-tumor cell line HEK-293 as well as in co-culture studies (HT-29/THP-1). All the compounds have been studied as PD-L1 (Programmed Death Ligand 1), VEGFR-2 (Vascular Endothelial Growth Factor 2), CD-47 (Cluster of Differentiation 47) and c-Myc inhibitors. The effect on TNF-α secretion has also been determined. Bromoderivatives 23, 24 and chloroderivatives 26, 27 have demonstrated an apoptotic effect on HT-29 cancer cells. Compounds bearing an amine group have shown very promising effects as TME immunomodulatory agents. | ca_CA |
dc.format.extent | 12 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Biomedicine & Pharmacotherapy Volume 169, 31 December 2023. | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | ca_CA |
dc.subject | Amine | ca_CA |
dc.subject | Antiproliferative activity | ca_CA |
dc.subject | Apoptosis | ca_CA |
dc.subject | C-Myc | ca_CA |
dc.subject | CD-47 | ca_CA |
dc.subject | PD-L1 | ca_CA |
dc.subject | Tetrazole | ca_CA |
dc.subject | THP-1 | ca_CA |
dc.subject | TNF-α | ca_CA |
dc.subject | VEGFR-2 | ca_CA |
dc.title | Tetrazole derivatives as potent immunomodulatory agents in tumor microenvironment | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | 10.1016/j.biopha.2023.115668 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S075333222301466X | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Generalitat Valenciana | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
project.funder.name | Ministerio de Ciencia e Innovación | ca_CA |
project.funder.name | European Regional Development Fund | ca_CA |
project.funder.name | Agencia Estatal de Investigación | ca_CA |
oaire.awardNumber | ACIF/2020/341 | ca_CA |
oaire.awardNumber | UJI-B2021–46 | ca_CA |
oaire.awardNumber | MCIN/AEI/ 10.13039/501100011033 | ca_CA |
dc.subject.ods | 3. Salud y bienestar | ca_CA |
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