Effect of Hyaluronic Acid on the Self-Assembly of a Dipeptide-Based Supramolecular Gel
comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Effect of Hyaluronic Acid on the Self-Assembly of a Dipeptide-Based Supramolecular GelDate
2023-10-02Publisher
WileyBibliographic citation
GIMÉNEZ‐HERNÁNDEZ, Bárbara; FALOMIR, Eva; ESCUDER, Beatriu. Effect of Hyaluronic Acid on the Self‐Assembly of a Dipeptide‐Based Supramolecular Gel. ChemBioChem, 2023, vol. 24, no 23, p. e202300438.Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
The combination of polymers and low molecular weight (LMW) compounds is a powerful approach to prepare new supramolecular materials. Here we prepare two-component hydrogels made by a well-known and biologically active ... [+]
The combination of polymers and low molecular weight (LMW) compounds is a powerful approach to prepare new supramolecular materials. Here we prepare two-component hydrogels made by a well-known and biologically active polymer, hyaluronic acid (HA), and a dipeptide-based supramolecular gelator. We undertake a detailed study of materials with different compositions including macroscopic (hydrogel formation, rheology) and micro/nanoscopic characterization (electron microscopy, X-ray powder diffraction). We observe that the two components mutually benefit in the new materials: a minimum amount of HA helps to reduce the polymorphism of the LMW network leading to reproducible hydrogels with improved mechanical properties; the LMW component network holds HA without the need for an irreversible covalent crosslinking. These materials have a great potential for biomedical application as, for instance, extracellular matrix mimetics for cell growth. As a proof of concept, we have observed that this material is effective for cell growth in suspension and avoids cell sedimentation even in the presence of competing cell-adhesive surfaces. This may be of interest to advanced cell delivery techniques. [-]
Funder Name
MCIN/AEI/10.13039/501100011033 | ERDF A way of making Europe | Universitat Jaume I
Project code
PID2019-110892RB-I00 | RTC-2017-6465-1 | UJI-B2020-21
Rights
© 2023 The Authors. ChemBioChem published by Wiley-VCH GmbH.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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