Reduction-Responsive Cationic Vesicles from Bolaamphiphiles with Ionizable Amino Acid or Dipeptide Polar Heads
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Reduction-Responsive Cationic Vesicles from Bolaamphiphiles with Ionizable Amino Acid or Dipeptide Polar HeadsData de publicació
2023Editor
ACS PublicationsCita bibliogràfica
Langmuir 2023, 39, 13841−13849Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://pubs.acs.org/doi/full/10.1021/acs.langmuir.3c01294Versió
info:eu-repo/semantics/publishedVersionResum
This paper presents a study of the aggregation of
cationic bolaamphiphilic molecules into vesicles. These molecules
are based on a cystamine core with protonated terminal dipeptide
groups. The study found that ... [+]
This paper presents a study of the aggregation of
cationic bolaamphiphilic molecules into vesicles. These molecules
are based on a cystamine core with protonated terminal dipeptide
groups. The study found that vesicles can be formed at pH 4 for all
of the dipeptide-terminated bolaamphiphiles containing different
combinations of L-valine, L-phenylalanine, and L-tryptophan. The
concentration for aggregation onset was determined by using
pyrene as a fluorescent probe or light dispersion for compounds
with tryptophan. Dynamic light scattering (DLS) studies and
transmission electron microscopy (TEM) reveal that the vesicles
have diameters ranging from 140 to 500 nm and show the capability of loading hydrophobic cargos, such as Nile red, and their
liberation in reductive environments. Furthermore, the bolaamphiphiles are only fully protonated and prone to vesicle formation at
acidic pH, making them a promising alternative for gastrointestinal delivery. [-]
Publicat a
Langmuir. 2023Entitat finançadora
Ministerio de Ciencia e Innovación
Codi del projecte o subvenció
RTI2018- 096748-B-I00 | PID2021-129033OB-I00 | PRE2019-090128
Drets d'accés
Copyright © 2023 The Authors. Published by American Chemical Society. This publication is licensed under
CC-BY 4.0.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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