Mediators of the association between maternal body mass index and breastfeeding duration in 3 international cohorts
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Scholar |
Otros documentos de la autoría: Keyes, Madeline; Andrews, Chloe; Midya, Vishal; Carrasco, Paula; Guxens, Mònica; Jimeno-Romero, Alba; Murcia, Mario; Rodriguez-Dehli, Cristina; Romaguera, Dora; Santa-Maria, Loreto; Vafeiadi, Marina; Chatzi, Lida; Oken, Emily; Vrijheid, Martine; Valvi, Damaskini; Sen, Sarbattama
Metadatos
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https://doi.org/10.1016/j.ajcnut.2023.04.004 |
Metadatos
Título
Mediators of the association between maternal body mass index and breastfeeding duration in 3 international cohortsAutoría
Fecha de publicación
2023-07Editor
ElsevierISSN
0002-9165; 1938-3207Cita bibliográfica
M. Keyes, C. Andrews, V. Midya, P. Carrasco, M. Guxens, A. Jimeno-Romero, et al., Mediators of the association between maternal body mass index and breastfeeding duration in 3 international cohorts, Am. J. Clin. Nutr. 118 (1) (2023) 255–263.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0002916523463332Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background:
Maternal obesity has been associated with shorter breastfeeding duration, but little is known about mediating factors explaining this association. It is important to assess these relationships across ... [+]
Background:
Maternal obesity has been associated with shorter breastfeeding duration, but little is known about mediating factors explaining this association. It is important to assess these relationships across diverse populations because breastfeeding is culturally patterned.
Objectives:
We investigated the association of prepregnancy maternal body mass index (BMI) with breastfeeding outcomes and potential mediators of this relationship in 3 culturally diverse international cohorts.
Methods:
We analyzed 5120 singleton pregnancies from mother–child cohorts in Spain (INfancia y Medio Ambiente), Greece (Rhea), and the United States (Project Viva). Outcome variables were duration of any and exclusive breastfeeding. A priori hypothesized mediators in the association of maternal prepregnancy BMI with breastfeeding were birthweight (BW), maternal prenatal C-reactive protein (CRP), cesarean delivery, maternal dietary inflammatory index (DII) during pregnancy, gestational age at delivery, and gestational diabetes mellitus (GDM). We estimated the association between BMI and breastfeeding duration using linear regression adjusting for confounders. Mediation analysis estimated direct and indirect effects of maternal overweight/obesity on breastfeeding for each mediator.
Results:
Women with overweight and obesity had shorter duration of any and exclusive breastfeeding compared with normal-weight women (any: overweight β = −0.79 mo, 95% CI: −1.17, −0.40; obese β = −1.75 mo 95% CI: −2.25, −1.25; exclusive: overweight β = −0.30 mo, 95% CI: −0.42, −0.16; obese β = −0.73 mo, 95% CI: −0.90, −0.55). Significant mediators (% change in effect estimate) of this association were higher CRP (exclusive: 5.12%), cesarean delivery (any: 6.54%; exclusive: 7.69%), and higher DII (any: 6.48%; exclusive: 7.69%). GDM, gestational age, and BW did not mediate the association of maternal weight status with breastfeeding.
Conclusions
Higher prepregnancy BMI is associated with shorter duration of any and exclusive breastfeeding. Maternal dietary inflammation, systemic inflammation, and mode of delivery may be key modifiable mediators of this association. Identification of mediators provides potential targets for interventions to improve breastfeeding outcomes. [-]
Publicado en
The American Journal of Clinical Nutrition, 2023, vol. 118, no 1Entidad financiadora
T32 | Project Viva | Nfancia y Medio Ambiente (INMA) | Instituto de Salud Carlos III | Generalitat Valenciana | Generalitat de Catalunya | Basque Government | Diputación Foral de Gipuzkoa | Fundación Roger Torné | Ministerio de Ciencia e Innovación | European Union | Greek Ministry of Health | Karolinska Institutet | Swedish Research Council | National Institute of Environmental Health Science
Código del proyecto o subvención
HD 098061 | P30ES023515 | UH3 OD 023286 | R01 HD 034568 | Red INMA G03/176 | CB06/02/0041 | FIS 97/0588 | 00/0021-2 | PI061756 | PS0901958 | FIS-FEDER 03/1615 | 04/1509 | 04/1112 | 04/1931 | 05/1079 | 05/1052 | 06/1213 | 07/0314 | 09/02647 | FIS-PI041436 | FIS-PI081151 | FIS-PI06/0867 | FIS-PS09/00090 | CPII18/00018 | 1999SGR 00241 | 2005111093 | 2009111069 | DFG06/004 | DFG08/001 | CEX2018-000806-S | EU FP6-2003-Food-3-NewGeneris | EU FP6. STREP Hiwate | EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape | EU FP7-2008-ENV 1.2.1.4 Envirogenomarkers | EU FP7-HEALTH-2009-single-stage CHICOS | EU FP7 ENV.2008.1.2.1.6. Proposal No. 226285 ENRIECO | EU-FP7-HEALTH-2012 Proposal No. 308333 HELIX | 2015-03655 | R01-ES029944 | R01-ES030691 | R01-ES030364 | R21-ES028903 | R21-ES029681 | P30-ES007048
Derechos de acceso
Copyright © American Society for Nutrition. Published by Elsevier Inc. All rights reserved.
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
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