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Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women
dc.contributor.author | Dineva, Mariana | |
dc.contributor.author | Rayman, Margaret | |
dc.contributor.author | Levie, Deborah | |
dc.contributor.author | Hunziker, Sandra | |
dc.contributor.author | Guxens, Mònica | |
dc.contributor.author | Peeters, Robin | |
dc.contributor.author | Murcia, Mario | |
dc.contributor.author | Rebagliato, Marisa | |
dc.contributor.author | Irizar Loibide, Amaia | |
dc.contributor.author | Jimeno-Romero, Alba | |
dc.contributor.author | Sunyer Deu, Jordi | |
dc.contributor.author | Korevaar, Tim | |
dc.contributor.author | Bath, Sarah | |
dc.date.accessioned | 2023-07-19T12:03:09Z | |
dc.date.available | 2023-07-19T12:03:09Z | |
dc.date.issued | 2023-03-27 | |
dc.identifier.citation | Dineva, M., Rayman, M.P., Levie, D. et al. Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women. Eur J Nutr 62, 2139–2154 (2023). https://doi.org/10.1007/s00394-023-03131-x | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/203398 | |
dc.description.abstract | Purpose Urinary iodine-to-creatinine ratio (UI/Creat) reflects recent iodine intake but has limitations for assessing habitual intake. Thyroglobulin (Tg) concentration, which increases with thyroid size, appears to be an indicator of longer-term iodine status in children and adults, however, less is known in pregnancy. This study investigated the determinants of serum-Tg in pregnancy and its use as an iodine-status biomarker in settings of iodine-sufficiency and mild-to-moderate deficiency. Methods Stored blood samples and existing data from pregnant women from the Netherlands-based Generation R (iodine-sufficient) and the Spain-based INMA (mildly-to-moderately iodine-deficient) cohorts were used. Serum-Tg and iodine status (as spot-urine UI/Creat) were measured at median 13 gestational weeks. Using regression models, maternal socio-demographics, diet and iodine-supplement use were investigated as determinants of serum-Tg, as well as the association between UI/Creat and serum-Tg. Results Median serum-Tg was 11.1 ng/ml in Generation R (n = 3548) and 11.5 ng/ml in INMA (n = 1168). When using 150 µg/g threshold for iodine deficiency, serum-Tg was higher in women with UI/Creat < 150 vs ≥ 150 µg/g (Generation R, 12.0 vs 10.4 ng/ml, P = 0.010; INMA, 12.8 vs 10.4 ng/ml, P < 0.001); after confounder adjustment, serum-Tg was still higher when UI/Creat < 150 µg/g (regression coefficients: Generation R, B = 0.111, P = 0.050; INMA, B = 0.157, P = 0.010). Iodine-supplement use and milk intake were negatively associated with serum-Tg, whereas smoking was positively associated. Conclusion The association between iodine status and serum-Tg was stronger in the iodine-deficient cohort, than in the iodine-sufficient cohort. Serum-Tg might be a complementary (to UI/Creat) biomarker of iodine status in pregnancy but further evidence is needed. | ca_CA |
dc.format.extent | 16 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Springer | ca_CA |
dc.relation | EUthyroid project | ca_CA |
dc.rights | © The Author(s) 2023 | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.subject | thyroglobulin | ca_CA |
dc.subject | iodine | ca_CA |
dc.subject | biomarkers | ca_CA |
dc.subject | pregnancy | ca_CA |
dc.subject | INMA | ca_CA |
dc.subject | generation R | ca_CA |
dc.title | Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1007/s00394-023-03131-x | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | European Union´s Horizon 2020 research and innovation programme | ca_CA |
project.funder.name | The Academy of Medical Sciences Springboard programme | ca_CA |
oaire.awardNumber | 634453 | ca_CA |
oaire.awardNumber | SBF005\1097 | ca_CA |
dc.subject.ods | 3. Salud y bienestar | |
dc.subject.ods | 5. Igualdad de género |
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