Evaluation of direct sample injection as a fast, no-sample handling, approach for the LC-MS/MS monitoring of pharmaceuticals in different water matrices
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Título
Evaluation of direct sample injection as a fast, no-sample handling, approach for the LC-MS/MS monitoring of pharmaceuticals in different water matricesFecha de publicación
2023Editor
ElsevierCita bibliográfica
SIMARRO-GIMENO, Claudia, et al. Evaluation of direct sample injection as a fast, no-sample handling, approach for the LC-MS/MS monitoring of pharmaceuticals in different water matrices. Microchemical Journal, 2023, p. 108985.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0026265X23006033Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The determination of drug residues in water, particularly in environmental water, is a hot topic due to the usual
presence of these emerging contaminants in the aquatic environment and their potential negative impact ... [+]
The determination of drug residues in water, particularly in environmental water, is a hot topic due to the usual
presence of these emerging contaminants in the aquatic environment and their potential negative impact on
water quality. The most widely approach applied at present for their determination is the use of a solid phase
extraction (SPE) step followed by the LC-MS/MS measurement. This is due to the theoretical need to preconcentrate the analytes and to produce “clean” sample extracts leading to less inferences in subsequent analysis. However, in LC-MS/MS based methods, the main interferences are not “visible” and are mostly due to
matrix effects, which in fact are produced by unknown compounds that co-elute with the analytes and therefore
not easily removed by SPE. As an alternative, an increasing trend is observed towards the use of direct injection
(DI) of the samples, which is nowadays possible thank to the notable improvement in sensitivity of modern LCMS/MS instrumentation.
In this work, both approaches, SPE and DI, have been evaluated for the determination of 16 pharmaceuticals in
three different types of water: groundwater, surface water and effluent wastewater. The study has been performed by using pharmaceutical reference standards and their corresponding isotope-labelled internal standards
(ILIS) for efficient matrix effects correction. Both methodologies have been compared in terms of matrix effects,
sensitivity, and suitability for the analysis of real-world water samples. Our data show that DI is an efficient
alternative to SPE, with satisfactory analyte recoveries for most pharmaceuticals, matrix effects even lower than
in SPE, and sufficient sensitivity for most of applications. In addition, the absence of sample treatment minimizes
potential errors associated with this step, and there is a notable saving in the analysis time and costs. The analysis
of Quality Control (QC) samples included in different sample batch sequences has been used to support the
feasibility of using DI in this type of analysis. [-]
Publicado en
Microchemical Journal, 2023Entidad financiadora
Universitat Jaume I | Ministerio de Ciencia e Innovación | Generalitat Valenciana
Código del proyecto o subvención
UJI-B2022-16 | PID2021-127451OB-I00 | Prometeo 2019/040
Derechos de acceso
info:eu-repo/semantics/openAccess
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