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Micellar liquid chromatography as a sustainable tool to quantify three statins in oral solid dosage forms
dc.contributor.author | García López , Lidia | |
dc.contributor.author | Peris Vicente, Juan | |
dc.contributor.author | Bose, Devasish | |
dc.contributor.author | Durgbanshi, Abhilasha | |
dc.contributor.author | Carda-Broch, Samuel | |
dc.date.accessioned | 2023-07-03T10:25:31Z | |
dc.date.available | 2023-07-03T10:25:31Z | |
dc.date.issued | 2023-04-20 | |
dc.identifier.citation | García-López, L., Peris-Vicente, J., Bose, D., Durgbanshi, A., & Carda-Broch, S. (2023). Micellar liquid chromatography as a sustainable tool to quantify three statins in oral solid dosage forms. Journal of Chromatography A, 1698, 464000. | ca_CA |
dc.identifier.issn | 0021-9673 | |
dc.identifier.issn | 1873-3778 | |
dc.identifier.uri | http://hdl.handle.net/10234/203021 | |
dc.description.abstract | A method based on micellar liquid chromatography has been developed to determine rosuvastatin, lovastatin and simvastatin in oral solid dosage forms. Samples were solved in mobile phase up to the target concentration, filtered and directly injected. The three statins were resolved in 30 min, using an aqueous solution of 0.10 M sodium dodecyl sulfate – 7.0% 1-butanol, buffered at pH 3 with 0.01 M phosphate salt as mobile phase, running under isocratic mode at 1 mL/min through a C18 column. Detection was at 240 nm. The effect of sodium dodecyl sulfate on elution strength was more important than that of the organic solvent. The procedure was successfully validated by the guidelines of the International Council for Harmonization in terms of: specificity, linearity (r2 > 0.990), calibration range (1.5 - 15 mg/L for rosuvastatin, 0.5–10 mg/L for lovastatin and simvastatin), limit of detection (0.4, 0.2 and 0.15 mg/L for rosuvastatin, lovastatin and simvastatin, respectively), trueness (98.8–101.7%), precision (<2.7%), carry-over effect, robustness, and stability. Values were inside the acceptance criteria of the Methods, Method Verification and Validation, Food and Drug Administration-Office of Regulatory Affairs, thus ensuring the reliability of the results. The main feature was the low proportion of organic solvent used, thus making the procedure sustainable and green. Besides, it was easy-to-conduct and with high sample-throughput, and then useful for routine analysis in pharmaceutical quality control. Finally, it was applied to commercial pharmaceutical preparations. | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Journal of Chromatography A Volume 1698, 7 June 2023, 464000 | ca_CA |
dc.relation.uri | Data will be made available on request. | ca_CA |
dc.rights | © 2023 The Author(s). Published by Elsevier B.V. | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.subject | lovastatin | ca_CA |
dc.subject | pharmaceutical | ca_CA |
dc.subject | rosuvastatin | ca_CA |
dc.subject | simvastatin | ca_CA |
dc.subject | validation | ca_CA |
dc.title | Micellar liquid chromatography as a sustainable tool to quantify three statins in oral solid dosage forms | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.chroma.2023.464000 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Ministerio de Ciencia, Innovación y Universidades | ca_CA |
project.funder.name | Department of Science and Technology, Ministry of Science and Technology, Government of India | ca_CA |
project.funder.name | Universitat de València | ca_CA |
oaire.awardNumber | PID2019-106708GB-I00 | ca_CA |
oaire.awardNumber | AEI/10.13039/501100011033 | ca_CA |
oaire.awardNumber | Sl.No.64 Dated 31-05-2016 | ca_CA |
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