Association between the Use of Folic Acid Supplements during Pregnancy and Children's Cognitive Function at 7-9 Years of Age in the INMA Cohort Study
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comunitat-uji-handle2:10234/36080
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Title
Association between the Use of Folic Acid Supplements during Pregnancy and Children's Cognitive Function at 7-9 Years of Age in the INMA Cohort StudyAuthor (s)
Date
2022-09-25Publisher
MDPIBibliographic citation
Compañ-Gabucio, L.M.; Torres-Collado, L.; Garcia-de la Hera, M.; Fernández-Somoano, A.; Tardón, A.; Julvez, J.; Sunyer, J.; Rebagliato, M.; Murcia, M.; Ibarluzea, J.; Santa-Marina, L.; Vioque, J. Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study. Int. J. Environ. Res. Public Health 2022, 19, 12123. https://doi.org/10.3390/ijerph191912123Type
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info:eu-repo/semantics/publishedVersionSubject
Abstract
This study investigated the association between maternal low (<400 μg/day) or high (≥1000 μg/day) folic acid supplements (FAs) use during pregnancy and the attentional function and working memory in boys and girls at ... [+]
This study investigated the association between maternal low (<400 μg/day) or high (≥1000 μg/day) folic acid supplements (FAs) use during pregnancy and the attentional function and working memory in boys and girls at age 7–9. A longitudinal analysis based on 1609 mother–child pairs from the Spanish Infancia y Medio Ambiente Project was carried out. Multivariable regression analyses revealed that, compared to the recommended FAs use, a low FAs use during the second period of pregnancy was associated with a lower alertness in all children (β = 18.70 ms; 95% CI: 7.51; 29.89) and in girls (β = 30.01 ms; 95% CI: 12.96; 47.01), and with a lower N-back Task performance in boys (d’ number 2-back (β = −0.25; 95% CI: −0.49; 0.01)). A high FAs use throughout the two periods of pregnancy was associated with a better N-back Task performance only in girls (d’ number 2-back (β = 0.28; 95% CI: 0.01; 0.56) and d’ number 3-back (β = 0.32; 95% CI: 0.08; 0.56)). The maternal use of FAs beyond the periconceptional period may affect children’s attentional function and working memory at age 7–9 differently for boys and girls. [-]
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Int. J. Environ. Res. Public Health 2022, 19(19)Funder Name
European Union | Institute of Health Carlos III (ISCiii) | Ministerio de Economía y Competitividad, España | FIS-FEDER | FEDER funds. | Miguel Servet-FEDER | Generalitat de Catalunya-CIRIT | CERCA Programme / Generalitat de Catalunya | Fundació La marató de TV3 | CIBERESP | Obra Social Cajastur/Fundación Liberbank | Universidad de Oviedo | Alicia Koplowitz Foundation 2017 | Department of Health of the Basque Government | Provincial Government of Gipuzkoa | European Regional Development Fund (ERDF) | Miguel Servet-II contract | Universidad Miguel Hernández
Project code
FP7-ENV-2011 cod 282957 | HEALTH.2010.2.4.5-1 | Red INMA G03/176 | CB06/02/0041 | PI03/1615 | PI04/1509 | PI04/1112 | PI04/1931 | PI04/2018 | PI05/1079 | PI05/1052 | PI06/1213 | PI06/0867 | PI07/0314 | PI09/02311 | PI09/02647 | PI11/01007 | PI11/02591 | PI11/02038 | PI12/00610 | PI13/02429 | PI13/1944 | PI13/2032 | PI14/00891 | PI14/01687 | PI16/1288 | PI17/00663 | PI04/1436 | PI08/1151 | PI04/2018 | PI09/02311 | PI13/02429 | FISS-19-PI18-00909 | PI18/01142 | PI09/00090 | CP11/00178 | CP15/00025 | CPII16/00051 | FISABIO UGP 15-230 | UGP-15-244 | UGP-15-249 | AICO/2021/347 | 1999SGR 00241 | 090430 | 2005111093 | 2013111089 | DFG06/002 | PI16/00261 | PI21/00266 | PI18/00909 | CPII19/00015
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