Elevated pulse pressure and cardiovascular risk associated in Spanish population attended in primary care: IBERICAN study
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Altres documents de l'autoria: Moyá Amengual, Ana; Ruiz-Garcia, Antonio; Pallarés-Carratalá, Vicente; Serrano-Cumplido, Adalberto; Prieto-Díaz, Miguel Ángel; Segura Fragoso, Antonio; Cinza-Sanjurjo, Sergio
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
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Elevated pulse pressure and cardiovascular risk associated in Spanish population attended in primary care: IBERICAN studyAutoria
Data de publicació
2023Editor
Frontiers MediaISSN
2297-055XCita bibliogràfica
Moyá-Amengual A, Ruiz-García A, Pallarés-Carratalá V, Serrano-Cumplido A, Prieto-Díaz MÁ, Segura-Fragoso A, CinzaSanjurjo S and the researchers of the IBERICAN study (2023) Elevated pulse pressure and cardiovascular risk associated in Spanish population attended in primary care: IBERICAN study. Front. Cardiovasc. Med. 10:1090458. doi: 10.3389/fcvm.2023.1090458Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Introduction: Elevated pulse pressure (ePP) is an independent marker of
cardiovascular risk (CVR) in people older than 60, and a functional marker of
subclinical target organ damage (sTOD) which can predict cardio ... [+]
Introduction: Elevated pulse pressure (ePP) is an independent marker of
cardiovascular risk (CVR) in people older than 60, and a functional marker of
subclinical target organ damage (sTOD) which can predict cardiovascular events
in patients with hypertension (HTN), regardless of sTOD.
Objective: To evaluate the prevalence of ePP in adult population seen in primary
care and its association with other vascular risk factors, sTOD and with
cardiovascular disease (CVD).
Materials and methods: Observational multicentre study conducted in Spain (8,066
patients, 54.5% women) from the prospective cohort study IBERICAN recruited in
Primary Care. Pulse pressure (PP) was defined as the difference between the systolic
blood pressure (SBP) and the diastolic blood pressure (DBP) ≥60 mmHg. Adjusted
(for age and sex) ePP prevalence were determined. Bivariate and multivariate
analyses of the possible variables associated with ePP were carried out.
Results: The mean of PP was 52.35 mmHg, and was significantly higher (p < 0.001) in
patients with HTN (56.58 vs. 48.45 mmHg) The prevalence of ePP adjusted for age and
sex was 23.54% (25.40% men vs. 21.75% women; p < 0.0001). The ePP prevalence
rates increased linearly with age (R2= 0.979) and were significantly more frequent in
population aged ≥65 than in population aged <65 (45.47% vs. 20.98%; p < 0.001).
HTN, left ventricular hypertrophy, low estimated glomerular filtration rate, alcohol
consumption, abdominal obesity, and CVD were independently associated with ePP.
66.27% of patients with ePP had a high or very high CVR, as compared with 36.57%
of patients without ePP (OR: 3.41 [95% CI 3.08–3.77]).
Conclusions: The ePP was present in a quarter of our sample, and it was increased
with the age. Also, the ePP was more frequent in men, patients with HTN, other
TOD (as left ventricular hypertrophy or low estimated glomerular filtration rate) and
CVD; because of this, the ePP was associated a higher cardiovascular risk. In our
opinion, the ePP is an importer risk marker and its early identification lets to
improve better diagnostic and therapeutic management. [-]
Publicat a
Frontiers in Cardiovascular Medicine, 10:1090458Drets d'accés
info:eu-repo/semantics/openAccess
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