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dc.contributor.authorSánchez-de-Lara-Sánchez, Sofía
dc.contributor.authorSánchez-Pérez, Ana María
dc.date.accessioned2023-05-16T10:33:34Z
dc.date.available2023-05-16T10:33:34Z
dc.date.issued2022-10-11
dc.identifier.citationSánchez-de-Lara-Sánchez, Sofía and Sánchez-Pérez, Ana María. ‘Probiotics Treatment Can Improve Cognition in Patients with Mild Cognitive Impairment: A Systematic Review’. 1 Jan. 2022 : 1173 – 1191.ca_CA
dc.identifier.issn1387-2877
dc.identifier.issn1875-8908
dc.identifier.urihttp://hdl.handle.net/10234/202511
dc.description.abstractBackground:In recent years, the existence of the gut-brain axis and the impact of intestinal microbiota on brain function has received much attention. Accumulated evidence has prompted the postulation of the infectious hypothesis underlying or facilitating neurodegenerative diseases, such as Alzheimer’s disease. Under this hypothesis, intervention with probiotics could be useful at a preventive and therapeutic level. Objective:The objective of this systematic review is to reveal a benefit of improved cognitive function following the use of probiotics in individuals with mild cognitive impairment. Methods:We searched bibliographic databases and analyzed in detail the evidence and methodological quality of five recent randomized, double-blind, placebo-controlled clinical trials using the Cochrane Tool and the SIGN checklist. Results:Overall, and with satisfactory methodological quality, the evaluated studies support the use of probiotics as a weapon to slow the progression of cognitive decline in subjects with mild cognitive impairment. The reviewed literature also indicates that maximum benefit of probiotics is found in subjects with incipient cognitive dysfunction and has no effect in those with advanced disease or absence of disease. Conclusion:These results support the intervention with probiotics, especially as a preventive approach. However, caution is required in the interpretation of the results as microbiota has not been evaluated in all studies, and further large-scale research with a prolonged study period is necessary to ensure the translatability of the results into real practice.ca_CA
dc.format.extent35 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherIOS Pressca_CA
dc.relation.isPartOfJournal of Alzheimer's Disease, vol. 89, no. 4, pp. 1173-1191, 2022ca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/ca_CA
dc.subjectAlzheimer’s diseaseca_CA
dc.subjectbrain-gut axisca_CA
dc.subjectcognitive dysfunctionca_CA
dc.subjectgastrointestinal microbiomeca_CA
dc.subjectprobioticsca_CA
dc.titleProbiotics Treatment Can Improve Cognition in Patients with Mild Cognitive Impairment: A Systematic Reviewca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.3233/JAD-220615
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.type.versioninfo:eu-repo/semantics/acceptedVersionca_CA
project.funder.nameUniversitat Jaume Ica_CA


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