Long Non-Coding RNAs, Extracellular Vesicles and Inflammation in Alzheimer’s Disease
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Otros documentos de la autoría: Canseco Rodriguez, Ania; Masola, Valeria; Aliperti, Vincenza; Meseguer Beltrán, Maria; DONIZETTI, Aldo; Sánchez-Pérez, Ana María
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INVESTIGACIONMetadatos
Título
Long Non-Coding RNAs, Extracellular Vesicles and Inflammation in Alzheimer’s DiseaseAutoría
Fecha de publicación
2022-10-29Editor
MDPICita bibliográfica
Canseco-Rodriguez, A.; Masola, V.; Aliperti, V.; Meseguer-Beltran, M.; Donizetti, A.; Sanchez-Perez, A.M. Long Non-Coding RNAs, Extracellular Vesicles and Inflammation in Alzheimer’s Disease. Int. J. Mol. Sci. 2022, 23, 13171. https://doi.org/ 10.3390/ijms232113171Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.mdpi.com/1422-0067/23/21/13171Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Alzheimer’s Disease (AD) has currently no effective treatment; however, preventive measures have the potential to reduce AD risk. Thus, accurate and early prediction of risk is an important strategy to alleviate the ... [+]
Alzheimer’s Disease (AD) has currently no effective treatment; however, preventive measures have the potential to reduce AD risk. Thus, accurate and early prediction of risk is an important strategy to alleviate the AD burden. Neuroinflammation is a major factor prompting the onset of the disease. Inflammation exerts its toxic effect via multiple mechanisms. Amongst others, it is affecting gene expression via modulation of non-coding RNAs (ncRNAs), such as miRNAs. Recent evidence supports that inflammation can also affect long non-coding RNA (lncRNA) expression. While the association between miRNAs and inflammation in AD has been studied, the role of lncRNAs in neurodegenerative diseases has been less explored. In this review, we focus on lncRNAs and inflammation in the context of AD. Furthermore, since plasma-isolated extracellular vesicles (EVs) are increasingly recognized as an effective monitoring strategy for brain pathologies, we have focused on the studies reporting dysregulated lncRNAs in EVs isolated from AD patients and controls. The revised literature shows a positive association between pro-inflammatory lncRNAs and AD. However, the reports evaluating lncRNA alterations in EVs isolated from the plasma of patients and controls, although still limited, confirm the value of specific lncRNAs associated with AD as reliable biomarkers. This is an emerging field that will open new avenues to improve risk prediction and patient stratification, and may lead to the discovery of potential novel therapeutic targets for AD. [-]
Publicado en
Int. J. Mol. Sci. 2022, 23(21), 13171Entidad financiadora
Universitat Jaume I | University of Naples
Código del proyecto o subvención
B2021-21
Derechos de acceso
© 2022 by the authors.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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