Structural But Not Functional Connectivity Differences within Default Mode Network Indicate Conversion to Dementia
comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONMetadades
Títol
Structural But Not Functional Connectivity Differences within Default Mode Network Indicate Conversion to DementiaData de publicació
2023-02-14Editor
IOS PressISSN
1387-2877; 1875-8908Cita bibliogràfica
Marin-Marin, Lidón, Miró-Padilla, Anna, and Costumero, Víctor. ‘Structural But Not Functional Connectivity Differences Within Default Mode Network Indicate Conversion to Dementia’. 1 Jan. 2023 : 1483 – 1494.Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/acceptedVersionParaules clau / Matèries
Resum
Background:Malfunctioning of the default mode network (DMN) has been consistently related to mild cognitive impairment (MCI) and Alzheimer’s disease (AD). However, evidence on differences in this network between MCI ... [+]
Background:Malfunctioning of the default mode network (DMN) has been consistently related to mild cognitive impairment (MCI) and Alzheimer’s disease (AD). However, evidence on differences in this network between MCI converters (MCI-c) and non-converters (MCI-nc), which could mark progression to AD, is still inconsistent. Objective:To multimodally investigate the DMN in the AD continuum. Methods:We measured gray matter (GM) volume, white matter (WM) integrity, and functional connectivity (FC) at rest in healthy elderly controls, MCI-c, MCI-nc, and AD patients, matched on sociodemographic variables. Results:Significant differences between AD patients and controls were found in the structure of most of the regions of the DMN. MCI-c only differed from MCI-nc in GM volume of the left parahippocampus and bilateral hippocampi and middle frontal gyri, as well as in WM integrity of the parahippocampal cingulum connecting the left hippocampus and precuneus. We found significant correlations between integrity in some of those regions and global neuropsychological status, as well as an excellent discrimination ability between converters and non-converters for the sum of GM volume of left parahippocampus, bilateral hippocampi, and middle frontal gyri, and WM integrity of left parahippocampal cingulum. However, we found no significant differences in FC. Conclusion:These results further support the relationship between abnormalities in the DMN and AD, and suggest that structural measures could be more accurate than resting-state estimates as markers of conversion from MCI to AD. [-]
Publicat a
Journal of Alzheimer's Disease, vol. 91, no. 4, pp. 1483-1494, 2023Entitat finançadora
Ministerio de Ciencia, Innovación y Universidades | Universitat Jaume I | Ministerio de Cultura y Deporte
Codi del projecte o subvenció
PID2019-105077RJ-I00 | POSDOC/2019/01 | FPU 17/00698
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info:eu-repo/semantics/openAccess
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