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LC-IMS-HRMS for identification of biomarkers in untargeted metabolomics: The effects of pterostilbene and resveratrol consumption in liver steatosis, animal model
dc.contributor.author | Lacalle-Bergeron, Leticia | |
dc.contributor.author | Izquierdo-Sandoval, David | |
dc.contributor.author | Fernandez-Quintela, Alfredo | |
dc.contributor.author | Portillo, Maria P | |
dc.contributor.author | Sancho, Juan V | |
dc.contributor.author | Hernandez, Felix | |
dc.contributor.author | Portoles, Tania | |
dc.date.accessioned | 2023-04-21T13:59:29Z | |
dc.date.available | 2023-04-21T13:59:29Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Lacalle-Bergeron L, Izquierdo-Sandoval D, Fernández-Quintela A, Portillo MP, Sancho JV, Hernández F, Portolés T. LC-IMS-HRMS for identification of biomarkers in untargeted metabolomics: The effects of pterostilbene and resveratrol consumption in liver steatosis, animal model. Food Res Int. 2023 Mar;165:112376. doi: 10.1016/j.foodres.2022.112376. Epub 2023 Jan 2. PMID: 36869462. | ca_CA |
dc.identifier.issn | 0963-9969 | |
dc.identifier.uri | http://hdl.handle.net/10234/202242 | |
dc.description.abstract | Untargeted metabolomics with the combination of ion mobility separation coupled to high resolution mass spectrometry (IMS-HRMS) was applied to investigate the impact of resveratrol and pterostilbene supplementation on the metabolic fingerprint of the Wistar rats liver with induced liver steatosis. RP-LC and HILIC in both ionisation modes were employed to analyse the liver samples (n = 40) from Wistar rats fed with a high-fat and high-fructose diet, supplemented or not with resveratrol and pterostilbene. After univariate and multivariate statistical analysis, 34 metabolites were highlighted in the different diets and elucidated. Despite the structural similarity, different alterations in liver metabolism were observed by the supplementations. Resveratrol treatment was characterised by the alteration in metabolism of 17 lysophospholipids, while pterostilbene affected some vitamins and derivatives, among others. IMS has demonstrated great potential in the elucidation process thanks to the additional structural descriptor the CCS (Å2), providing more confidence in the identification. | ca_CA |
dc.format.extent | 12 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Food Research International. 2023 Mar;165:112376 | ca_CA |
dc.rights | © 2023 Elsevier Ltd. All rights reserved | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | ca_CA |
dc.rights.uri | ||
dc.subject | HRMS | ca_CA |
dc.subject | ion mobility | ca_CA |
dc.subject | liver steatosis | ca_CA |
dc.subject | pterostilbene | ca_CA |
dc.subject | resveratrol | ca_CA |
dc.subject | untargeted metabolomics | ca_CA |
dc.title | LC-IMS-HRMS for identification of biomarkers in untargeted metabolomics: The effects of pterostilbene and resveratrol consumption in liver steatosis, animal model | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.foodres.2022.112376 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/acceptedVersion | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
project.funder.name | Ministry of Science , Innovation and Universities of Spain | ca_CA |
project.funder.name | Ministry of Economy and Competitiveness, Spain | ca_CA |
project.funder.name | Generalitat Valenciana | ca_CA |
project.funder.name | University of the Basque Country | ca_CA |
project.funder.name | Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional | ca_CA |
project.funder.name | CIBERobn | ca_CA |
oaire.awardNumber | UJI 19I001 /03 | ca_CA |
oaire.awardNumber | FPU19 / 01839 | ca_CA |
oaire.awardNumber | RYC -2017 -22525 | ca_CA |
oaire.awardNumber | PROMETEO/2019 /040 | ca_CA |
oaire.awardNumber | UJI-B2020-25 | ca_CA |
oaire.awardNumber | UJI-B2020-37 | ca_CA |
oaire.awardNumber | GIU 18 /173 | ca_CA |
oaire.awardNumber | AGL-2015-6571 9-R MINECO /FEDER, UE | ca_CA |
oaire.awardNumber | CB12/03/30007 | ca_CA |
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