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Vitamin D supplementation and Its impact on mortality and cardiovascular outcomes: systematic review and meta-analysis of 80 randomized clinical trials
dc.contributor.author | Ruiz-Garcia, Antonio | |
dc.contributor.author | Pallarés-Carratalá, Vicente | |
dc.contributor.author | Turégano-Yedro, Miguel | |
dc.contributor.author | Torres, Ferran | |
dc.contributor.author | Sapena, Víctor | |
dc.contributor.author | Martin-Gorgojo, Alejandro | |
dc.contributor.author | Martin-Moreno, Jose M. | |
dc.date.accessioned | 2023-04-18T11:09:46Z | |
dc.date.available | 2023-04-18T11:09:46Z | |
dc.date.issued | 2023-04-07 | |
dc.identifier.citation | Ruiz-García, A.; Pallarés-Carratalá, V.; Turégano-Yedro, M.; Torres, F.; Sapena, V.; Martin-Gorgojo, A.; Martin-Moreno, J.M. Vitamin D Supplementation and Its Impact on Mortality and Cardiovascular Outcomes: Systematic Review and Meta-Analysis of 80 Randomized Clinical Trials. Nutrients 2023, 15, 1810. | ca_CA |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | http://hdl.handle.net/10234/202190 | |
dc.description.abstract | Background: The impact of vitamin D supplementation on cardiovascular outcomes and mortality risk reduction remains unclear due to conflicting study findings. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), published between 1983 and 2022, that reported the effect of vitamin D supplementation in adults versus placebo or no treatment on all-cause mortality (ACM), cardiovascular mortality (CVM), non-cardiovascular mortality (non-CVM), and cardiovascular morbidities. Only studies with a follow-up period longer than one year were included. The primary outcomes were ACM and CVM. Secondary outcomes were non-CVM, myocardial infarction, stroke, heart failure, and major or extended adverse cardiovascular events. Subgroup analyses were performed according to low-, fair- and good-quality RCTs. Results: Eighty RCTs were assessed, including 82,210 participants receiving vitamin D supplementation and 80,921 receiving placebo or no treatment. The participants’ mean (SD) age was 66.1 (11.2) years, and 68.6% were female. Vitamin D supplementation was associated with a lower risk of ACM (OR: 0.95 [95%CI 0.91–0.99] p = 0.013), was close to statistical significance for a lower risk of non-CVM (OR: 0.94 [95%CI 0.87–1.00] p = 0.055), and was not statistically associated with a lower risk of any cardiovascular morbi-mortality outcome. Meta-analysis of low-quality RCTs showed no association with cardiovascular or non-cardiovascular morbi-mortality outcomes. Conclusions: The emerging results of our meta-analysis present evidence that vitamin D supplementation appears to decrease the risk of ACM (especially convincing in the fair- and good-quality RCTs), while not showing a decrease in the specific cardiovascular morbidity and mortality risk. Thus, we conclude that further research is warranted in this area, with well-planned and executed studies as the basis for more robust recommendations. | ca_CA |
dc.format.extent | 16 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | MDPI | ca_CA |
dc.relation.isPartOf | Nutrients 2023, Vol. 15 (8) | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.subject | vitamin D | ca_CA |
dc.subject | all-cause mortality | ca_CA |
dc.subject | cardiovascular mortality | ca_CA |
dc.subject | myocardial infarction | ca_CA |
dc.subject | stroke | ca_CA |
dc.subject | heart failure | ca_CA |
dc.subject | major adverse cardiovascular events | ca_CA |
dc.subject | systematic review | ca_CA |
dc.subject | meta-analysis | ca_CA |
dc.title | Vitamin D supplementation and Its impact on mortality and cardiovascular outcomes: systematic review and meta-analysis of 80 randomized clinical trials | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.3390/nu15081810 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
dc.subject.ods | 3. Salud y bienestar |
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