Central nervous system stimulation therapies in phantom limb pain: a systematic review of clinical trials
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Other documents of the author: García - Pallero, Maria A.; Cardona, Diana; Rueda-Ruzafa, Lola; Rodriguez-Arrastia, Miguel; Roman, Pablo
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Title
Central nervous system stimulation therapies in phantom limb pain: a systematic review of clinical trialsAuthor (s)
Date
2022Publisher
Medknow PublicationsBibliographic citation
García-Pallero MÁ, Cardona D, Rueda-Ruzafa L, Rodriguez-Arrastia M, Roman P (2022) Central nervous system stimulation therapies in phantom limb pain: a systematic review of clinical trials. Neural Regen Res 17(1):59-64.Type
info:eu-repo/semantics/articlePublisher version
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451556/Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Phantom limb pain is a chronic pain syndrome that is difficult to cope with. Despite
neurostimulation treatment is indicated for refractory neuropathic pain, there is scant
evidence from randomized controlled trials ... [+]
Phantom limb pain is a chronic pain syndrome that is difficult to cope with. Despite
neurostimulation treatment is indicated for refractory neuropathic pain, there is scant
evidence from randomized controlled trials to recommend it as the treatment choice.
Thus, a systematic review was performed to analyze the efficacy of central nervous
system stimulation therapies as a strategy for pain management in patients with phantom
limb pain. A literature search for studies conducted between 1970 and September 2020
was carried out using the MEDLINE and Embase databases. Principles of The Preferred
Reporting Items for Systematic Reviews and Meta-Analyses guideline were followed.
There were a total of 10 full-text articles retrieved and included in this review. Deep
brain stimulation, repetitive transcranial magnetic stimulation, transcranial direct current
stimulation, and motor cortex stimulation were the treatment strategies used in the
selected clinical trials. Repetitive transcranial magnetic stimulation and transcranial
direct current stimulation were effective therapies to reduce pain perception, as well as
to relieve anxiety and depression symptoms in phantom limb pain patients. Conversely,
invasive approaches were considered the last treatment option as evidence in deep
brain stimulation and motor cortex stimulation suggests that the value of phantom limb
pain treatment remains controversial. However, the findings on use of these treatment
strategies in other forms of neuropathic pain suggest that these invasive approaches could
be a potential option for phantom limb pain patients. [-]
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Neural Regeneration Research, 2022, 17(1).Rights
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