Altered frontoparietal connectivity in patients with obsessive-compulsive disorder during an fMRI cognitive reappraisal task
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INVESTIGACIONMetadatos
Título
Altered frontoparietal connectivity in patients with obsessive-compulsive disorder during an fMRI cognitive reappraisal taskAutoría
Fecha de publicación
2022-10Editor
ElsevierCita bibliográfica
PICÓ-PÉREZ, Maria, et al. Altered frontoparietal connectivity in patients with obsessive-compulsive disorder during an fMRI cognitive reappraisal task. Psychiatry Research, 2022, vol. 317, p. 114874.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0165178122004668Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Patients with obsessive-compulsive disorder (OCD) present increased brain activity in orbitofrontal and limbic regions when experiencing negative emotions, which could be related to deficits in emotion regulation ... [+]
Patients with obsessive-compulsive disorder (OCD) present increased brain activity in orbitofrontal and limbic regions when experiencing negative emotions, which could be related to deficits in emotion regulation abilities. 30 OCD patients and 29 healthy controls (HC) performed a cognitive reappraisal functional magnetic resonance imaging (fMRI) task and completed emotion regulation and OCD symptomatology questionnaires. Besides task activation, connectivity was also compared between groups through psychophysiological interaction analysis (PPI), using regions previously reported to be hyperactive in OCD as seeds. Finally, brain-behavior correlations were performed between activation/connectivity strength in group differential regions and the questionnaires’ scores, as well as the emotional ratings reported during the task. Behaviorally, patients with OCD were less successful than controls at lowering the emotional impact of negative images. At the brain level, there were no significant between-group differences in brain activation. Contrarily, PPI analyses showed that HC had increased frontoparietal connectivity when experiencing negative emotions in comparison to OCD patients, while this pattern was reversed when regulating emotions (increased connectivity in patients). Finally, frontoparietal connectivity was correlated with measures of emotion regulation success and OCD symptomatology. Our findings point towards frontoparietal altered connectivity as a potential compensatory mechanism during emotion regulation in OCD patients. [-]
Publicado en
Psychiatry Research Volume 317, November 2022.Entidad financiadora
FLAD Science Award Mental Health 2021 | National funds, through the Foundation for Science and Technology | Norte Portugal Regional Operational Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) | 2-CA Clinical Academic Center (Portugal) | Ministerio de Universidades
Código del proyecto o subvención
UIDB/50026/2020 | UIDP/50026/2020 | NORTE-01-0145-FEDER-000039 | MAZ/2021/11
Derechos de acceso
info:eu-repo/semantics/openAccess
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