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dc.contributor.authorMeseguer Beltrán, Maria
dc.contributor.authorSánchez-Sarasúa, Sandra
dc.contributor.authorLandry, Marc
dc.contributor.authorKerekes, Nóra
dc.contributor.authorSánchez-Pérez, Ana María
dc.date.accessioned2023-02-02T12:03:20Z
dc.date.available2023-02-02T12:03:20Z
dc.date.issued2023-01-31
dc.identifier.citationMeseguer-Beltrán, M.; Sánchez-Sarasúa, S.; Landry, M.; Kerekes, N.; Sánchez-Pérez, A.M. Targeting Neuroinflammation with Abscisic Acid Reduces Pain Sensitivity in Females and Hyperactivity in Males of An ADHD Mice Model. Cells 2023, 12, 465. https://doi.org/10.3390/cells12030465ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/201521
dc.description.abstractAttention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental syndrome characterized by dopaminergic dysfunction. In this study, we aimed to demonstrate that there is a link between dopaminergic deficit and neuroinflammation that underlies ADHD symptoms. We used a validated ADHD mice model involving perinatal 6-OHDA lesions. The animals received abscisic acid (ABA), an anti-inflammatory phytohormone, at a concentration of 20 mg/L (drinking water) for one month. We tested a battery of behavior tests, learning and memory, anxiety, social interactions, and pain thresholds in female and male mice (control and lesioned, with or without ABA treatment). Postmortem, we analyzed microglia morphology and Ape1 expression in specific brain areas related to the descending pain inhibitory pathway. In females, the dopaminergic deficit increased pain sensitivity but not hyperactivity. In contrast, males displayed hyperactivity but showed no increased pain sensitivity. In females, pain sensitivity was associated with inflammatory microglia and lower Ape1 levels in the anterior cingulate cortex (ACC) and posterior insula cortex (IC). In addition, ABA treatment alleviated pain sensitivity concomitant with reduced inflammation and normalized APE1. In males, ABA reduced hyperactivity but had no significant effect on inflammation in these areas. This is the first study proving a sex-dependent association between dopamine dysfunction and inflammation in specific brain areas, hence leading to different behavioral outcomes in a mouse model of ADHD. These findings provide new clues for potential treatments for ADHD.ca_CA
dc.format.extent21 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherMDPIca_CA
dc.relation.isPartOfCells 2023, 12(3)ca_CA
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerlandca_CA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/ca_CA
dc.subjectattention deficit/hyperactivity disorder (ADHD)ca_CA
dc.subjectmicrogliaca_CA
dc.subjectoxidative stressca_CA
dc.subjectApe1ca_CA
dc.subjectpain sensitivityca_CA
dc.subjecthyperactivityca_CA
dc.subjectnovel object recognitionca_CA
dc.subjectspatial memoryca_CA
dc.subjectneuroinflammationca_CA
dc.titleTargeting Neuroinflammation with Abscisic Acid Reduces Pain Sensitivity in Females and Hyperactivity in Males of An ADHD Mice Modelca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.3390/cells12030465
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA
project.funder.nameKoplowitz Foundationca_CA


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© 2023 by the authors. Licensee MDPI, Basel, Switzerland
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