Is DRN the ignored target in Alzheimer's disease? Behavioral analysis and astroglial characterization in the female 3xTgAD model
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/158176
comunitat-uji-handle2:10234/71345
comunitat-uji-handle3:10234/163799
comunitat-uji-handle4:
TFG-TFMMetadatos
Título
Is DRN the ignored target in Alzheimer's disease? Behavioral analysis and astroglial characterization in the female 3xTgAD modelAutoría
Tutor/Supervisor; Universidad.Departamento
Ros Bernal, Francisco de Asís; Universitat Jaume I. Unitat Predepartamental de MedicinaFecha de publicación
2022-09-08Editor
Universitat Jaume IResumen
Astrocytes are responsible for the optimal functioning of the brain and its homeostasis, mobilizing in a "reactive" manner
in the face of lesions or diseases of the central nervous system. Thus, reactive astrogliosis ... [+]
Astrocytes are responsible for the optimal functioning of the brain and its homeostasis, mobilizing in a "reactive" manner
in the face of lesions or diseases of the central nervous system. Thus, reactive astrogliosis (RA) would be at the center
of the pathophysiology of Alzheimer's disease (AD), in addition to being an early event in its progression, preceding
other neuropathological features of the disease. The aim of this work is: first, to measure at the behavioral level if there
are differences in baseline memory (NOR) in control and 3xTgAD mice (9,12,15 months). Second, to characterize
astroglial morphology, which is thought to predate the formation of amyloid plaques. Finally, to correlate the number
of beta-amyloid-positive deposits and GFAP cells. This is intended to avoid the characteristic "hippocampal dogma" in
addressing the etiology of AD. In the NOR test phase, while animals in the control group discriminated perfectly
between both objects in all time frames analyzed, 3xTgAD animals showed alterations in reference memory, preferring
to visit the familiar object. The results obtained do not show us any really relevant morphological or quantitative pattern,
so we raise one more question: could it be that the change of these trends in complexity, lacunae, area and perimeter is
related not to the morphology of the astroglia per se, but to its morphology in relation to the proximity of the BA
plaques? In future studies we intend to observe these changes in relation to the proximity of BA plaques to find a
prototypical framework that will help us to discover which morphological changes underlie the process of
transformation from a "healthy" to a reactive astrogliosis in relation to its neuroprotective or neurotoxic functions, which
will give us much information about its response mechanism and thus facilitate the search for new therapeutic treatments
for AD. [-]
Palabras clave / Materias
Descripción
Treball Final de Màster Universitari en Investigació en Cervell i Conducta (Pla de 2021). SBT024. Curs: 2021/2022
Tipo de documento
info:eu-repo/semantics/masterThesisDerechos de acceso
info:eu-repo/semantics/openAccess