Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processes
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
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comunitat-uji-handle3:10234/8619
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Título
Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processesAutoría
Fecha de publicación
2022Editor
ElsevierISSN
2352-4928Cita bibliográfica
GARCÍA-ARNÁEZ, I., et al. Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processes. Materials Today Communications, 2022, vol. 33, p. 104674Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S235249282201515XVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Strontium plays an important role in bone regeneration; it promotes the differentiation and maturation of osteoblasts and inhibits the activity of osteoclasts. Our principal objective in this study was to formulate ... [+]
Strontium plays an important role in bone regeneration; it promotes the differentiation and maturation of osteoblasts and inhibits the activity of osteoclasts. Our principal objective in this study was to formulate new organic-inorganic hybrid sol-gel coatings applied to titanium discs. These coatings were functionalised with different amounts of SrCl2 and examined using in vitro tests and proteomics. The chemical and morphological characteristics of obtained coatings were scrutinised. The in vitro evaluation using the MC3T3-E1 osteoblasts and RAW264.7 macrophages showed the osteogenic and anti-inflammatory effects of strontium doping. The proteomic assay identified 111 different proteins adhering to the coatings. Six of these proteins reduced their adhesion affinity as a result of Sr-doping, whereas 40 showed increased affinity. Moreover, the proteomic analysis revealed osteogenic and anti-inflammatory properties of these biomaterials. The analysis also showed increased adhesion of proteins related to the coagulation system. We can conclude that proteomic methods are invaluable in developing new biomaterials and represent an important tool for predicting the biocompatibility of dental implants. [-]
Publicado en
Materials Today Communications, 2022, vol. 33, p. 104674Entidad financiadora
Ministerio de Ciencia, Innovación y Universidades | Ministerio de Economía y Competitividad | Generalitat Valenciana | Gobierno Vasco | Universitat Jaume I
Código del proyecto o subvención
RTC-2017-6147-1 | PID2020-113092RB-C21 | APOSTD/2020/036 | PRE_2016_1_0141 | UJI-B2021-25 | PROMETEO/2020/069
Derechos de acceso
info:eu-repo/semantics/openAccess
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