Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processes
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Other documents of the author: García-Arnáez, Iñaki; Cerqueira, Andreia; Romero-Gavilán, Francisco J; Elortza, Felix; Azkargorta, Mikel; Iloro, Ibon; Suay, Julio; Goñi, Isabel; GURRUCHAGA, MARILO
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7034
comunitat-uji-handle3:10234/8619
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INVESTIGACIONMetadata
Title
Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processesAuthor (s)
Date
2022Publisher
ElsevierISSN
2352-4928Bibliographic citation
GARCÍA-ARNÁEZ, I., et al. Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processes. Materials Today Communications, 2022, vol. 33, p. 104674Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S235249282201515XVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Strontium plays an important role in bone regeneration; it promotes the differentiation and maturation of osteoblasts and inhibits the activity of osteoclasts. Our principal objective in this study was to formulate ... [+]
Strontium plays an important role in bone regeneration; it promotes the differentiation and maturation of osteoblasts and inhibits the activity of osteoclasts. Our principal objective in this study was to formulate new organic-inorganic hybrid sol-gel coatings applied to titanium discs. These coatings were functionalised with different amounts of SrCl2 and examined using in vitro tests and proteomics. The chemical and morphological characteristics of obtained coatings were scrutinised. The in vitro evaluation using the MC3T3-E1 osteoblasts and RAW264.7 macrophages showed the osteogenic and anti-inflammatory effects of strontium doping. The proteomic assay identified 111 different proteins adhering to the coatings. Six of these proteins reduced their adhesion affinity as a result of Sr-doping, whereas 40 showed increased affinity. Moreover, the proteomic analysis revealed osteogenic and anti-inflammatory properties of these biomaterials. The analysis also showed increased adhesion of proteins related to the coagulation system. We can conclude that proteomic methods are invaluable in developing new biomaterials and represent an important tool for predicting the biocompatibility of dental implants. [-]
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Materials Today Communications, 2022, vol. 33, p. 104674Funder Name
Ministerio de Ciencia, Innovación y Universidades | Ministerio de Economía y Competitividad | Generalitat Valenciana | Gobierno Vasco | Universitat Jaume I
Project code
RTC-2017-6147-1 | PID2020-113092RB-C21 | APOSTD/2020/036 | PRE_2016_1_0141 | UJI-B2021-25 | PROMETEO/2020/069
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info:eu-repo/semantics/openAccess
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