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Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain
dc.contributor.author | García-González, Diego | |
dc.contributor.author | Dumitru, Ionut | |
dc.contributor.author | Zuccotti, Annalisa | |
dc.contributor.author | Yen, Ting-Yu | |
dc.contributor.author | Herranz-Pérez, Vicente | |
dc.contributor.author | Tan, Linette Liqi | |
dc.contributor.author | Angela, Neitz | |
dc.contributor.author | García-Verdugo, Jose Manuel | |
dc.contributor.author | Kuner, Rohini | |
dc.contributor.author | Alfonso, Julieta | |
dc.contributor.author | Monyer, Hannah | |
dc.date.accessioned | 2023-01-10T19:42:20Z | |
dc.date.available | 2023-01-10T19:42:20Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | GARCÍA-GONZÁLEZ, Diego, et al. Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain. Molecular psychiatry, 2021, vol. 26, núm. 9, p. 4616-4632 | ca_CA |
dc.identifier.issn | 1359-4184 | |
dc.identifier.issn | 1476-5578 | |
dc.identifier.uri | http://hdl.handle.net/10234/201337 | |
dc.description.abstract | In mammals, most adult neural stem cells (NSCs) are located in the ventricular–subventricular zone (V-SVZ) along the wall of the lateral ventricles and they are the source of olfactory bulb interneurons. Adult NSCs exhibit an apico-basal polarity; they harbor a short apical process and a long basal process, reminiscent of radial glia morphology. In the adult mouse brain, we detected extremely long radial glia-like fibers that originate from the anterior–ventral V-SVZ and that are directed to the ventral striatum. Interestingly, a fraction of adult V-SVZ-derived neuroblasts dispersed in close association with the radial glia-like fibers in the nucleus accumbens (NAc). Using several in vivo mouse models, we show that newborn neurons integrate into preexisting circuits in the NAc where they mature as medium spiny neurons (MSNs), i.e., a type of projection neurons formerly believed to be generated only during embryonic development. Moreover, we found that the number of newborn neurons in the NAc is dynamically regulated by persistent pain, suggesting that adult neurogenesis of MSNs is an experience-modulated process. | ca_CA |
dc.format.extent | 17 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Springer Nature | ca_CA |
dc.relation.isPartOf | Molecular psychiatry, 2021, vol. 26, núm. 9, p. 4616-4632 | ca_CA |
dc.rights | © The Author(s) 2020. This article is published with open access, corrected publication 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.title | Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1038/s41380-020-0823-4 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.nature.com/articles/s41380-020-0823-4 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Ministry of Science and Technology, Taiwan | ca_CA |
project.funder.name | Deutsche Forschungsgemeinschaft (DFG) | ca_CA |
project.funder.name | German Federal Ministry for Education and Research | ca_CA |
oaire.awardNumber | 108–2911-I-010–504 | ca_CA |
oaire.awardNumber | SFB1158 | ca_CA |
oaire.awardNumber | 01GQ1405 | ca_CA |
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Excepto si se señala otra cosa, la licencia del ítem se describe como: © The Author(s) 2020. This article is published with open access, corrected publication 2021.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.