Becoming a mother shifts the activity of the social and motivation brain networks in mice
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Otros documentos de la autoría: Navarro-Moreno, Cinta; Barneo-Muñoz, Manuela; Ibáñez Gual, Maria Victoria; Lanuza, Enrique; Agustín-Pavón, Carmen; Sánchez-Catalán, María José; Martinez-Garcia, Fernando
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Título
Becoming a mother shifts the activity of the social and motivation brain networks in miceAutoría
Fecha de publicación
2022-06-03Editor
ElsevierCita bibliográfica
NAVARRO-MORENO, Cinta, et al. Becoming a mother shifts the activity of the social and motivation brain networks in mice. iScience, 2022, p. 104525.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
During pregnancy hormones increase motivated pup-directed behaviors. We here analyze hormone-induced changes in brain activity, by comparing cFos-immunoreactivity in the sociosexual (SBN) and motivation brain networks ... [+]
During pregnancy hormones increase motivated pup-directed behaviors. We here analyze hormone-induced changes in brain activity, by comparing cFos-immunoreactivity in the sociosexual (SBN) and motivation brain networks (including medial preoptic area, MPO) of virgin versus late-pregnant pup-naïve female mice exposed to pups or buttons (control). Pups activate more the SBN than buttons in both late-pregnant and virgin females. By contrast, pregnancy increases pup-elicited activity in the motivation circuitry (e.g. accumbens core) but reduces button-induced activity and, consequently, button investigation. Principal components analysis supports the identity of the social and motivation brain circuits, placing the periaqueductal gray between both systems. Linear discriminant analysis of cFos-immunoreactivity in the socio-motivational brain network predicts the kind of female and stimulus better than the activity of the MPO alone; this suggests that the neuroendocrinological basis of social (e.g. maternal) behaviors conforms to a neural network model, rather than to distinct hierarchical linear pathways for different behaviors. [-]
Publicado en
iScience, Volume 25, Issue 7, 2022Entidad financiadora
Ministerio de Ciencia, Innovación y Universidades (Spain) | Generalitat Valenciana | Universitat Jaume I
Código del proyecto o subvención
PID2019-107322GB-C21 | PID2019-108562GB-I00 | GV-2020-173 | UJI-A2019-14 | UJI-B2020-22
Derechos de acceso
2022 The
Author(s).
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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