Inhibition of the medial amygdala disrupts escalated aggression in lactating female mice after repeated exposure to male intruders
Ver/ Abrir
Impacto
Scholar |
Otros documentos de la autoría: Abellán-Álvaro, María; Martinez-Garcia, Fernando; Agustín-Pavón, Carmen
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Inhibition of the medial amygdala disrupts escalated aggression in lactating female mice after repeated exposure to male intrudersFecha de publicación
2022-09-16Editor
Nature ResearchCita bibliográfica
Abellán-Álvaro, M., Martínez-García, F., Lanuza, E. et al. Inhibition of the medial amygdala disrupts escalated aggression in lactating female mice after repeated exposure to male intruders. Commun Biol 5, 980 (2022). https://doi.org/10.1038/s42003-022-03928-2Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Virgin female laboratory mice readily express pup care when co-housed with dams and pups. However, pup-sensitized virgins fail to express intruder-directed aggression on a single session of testing. To study whether ... [+]
Virgin female laboratory mice readily express pup care when co-housed with dams and pups. However, pup-sensitized virgins fail to express intruder-directed aggression on a single session of testing. To study whether repeated testing would affect the onset and dynamics of maternal or intruder-directed aggression, we tested dams and their accompanying virgins from postpartum day 4 to 6. Repeated testing led to escalated aggression towards male intruders in dams, but virgins never developed aggression. In dams, inhibition of the medial amygdala using DREADD (designer receptors exclusively activated by designer drugs) vectors carrying the hM4Di receptor blocked the expected increase in maternal aggression on the second testing day. Our data support that the onset of maternal aggression is linked to physiological changes occurring during motherhood, and that medial amygdala, a key centre integrating vomeronasal, olfactory and hormonal information, enables the expression of escalated aggression induced by repeated testing. Future studies selectively targeting specific neuronal populations of the medial amygdala are needed to allow a deeper understanding of the control of experience-dependent aggression increase, a phenomenon leading to the high aggression levels found in violent behaviours. [-]
Publicado en
Commun Biol 5, 980 (2022)Entidad financiadora
MCIN/AEI/10.13039/501100011033
Código del proyecto o subvención
PID2019-107322GB-C22 | PID2019-107322GB-C21 | PID2019-108562GB-I00
Derechos de acceso
© The Author(s) 2022
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- MED_Articles [655]