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Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish
dc.contributor.author | Sierra, Saleta | |
dc.contributor.author | Alfaro, Juan M. | |
dc.contributor.author | Sánchez, Sonia | |
dc.contributor.author | Burgos, Javier S. | |
dc.date.accessioned | 2022-10-18T11:05:34Z | |
dc.date.available | 2022-10-18T11:05:34Z | |
dc.date.issued | 2012-08-01 | |
dc.identifier.citation | Sierra, S., Alfaro, J. M., Sánchez, S., and Burgos, J. S. (2012) Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish. Brain Res Bull., 88, 5, 467-470 DOI: 10.1016/j.brainresbull.2012.04.007 | ca_CA |
dc.identifier.issn | 0361-9230 | |
dc.identifier.uri | http://hdl.handle.net/10234/200440 | |
dc.description.abstract | Docosahexaeonic acid (DHA) is the final compound in the omega-3 polyunsaturated fatty acids (PUFA) synthetic pathway and the most abundant PUFA found in the brain. DHA plays an essential role in the development of the brain, and the intakes in pregnancy and early life affect growth and cognitive performance later in childhood. Recently, it has been proposed that dietary intake of DHA could be a non-pharmacological interventional strategy for the treatment of seizures in humans. However, to date, the experimental approaches to study the antiepileptic effect of DHA have been exclusively restricted to rodent models during short-to-medium periods of treatment. The purpose of the present study was to test the chronic anticonvulsivant effects of DHA supplementation in zebrafish from the pre-spawning stage to aging, taking advantage of our recently described kainate-induced seizure model using this animal. To that end, two groups of adult female zebrafish were fed with standard or 200 mg/kg DHA-enriched diets during 1 month previous to the spawning, and offspring subdivided in two categories, and subsequently fed with standard or DHA diets, generating 4 groups of animals that were aged until 20 months. Afterward, KA was intraperitoneally administered and epileptic score determined. All the DHA-enriched groups presented antiepileptic effects compared to the control group, showing that DHA presents an anticonvulsant potential. Among the studied groups, zebrafish fed with DHA from the pre-spawning stage to aging presented the best antiepileptic profile. These results show a neuroprotective benefit in zebrafish fed with DHA-enriched diet before birth and during the whole life. | ca_CA |
dc.format.extent | 4 p. | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Brain Research Bulletin, 2012, vol. 88, no 5 | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | ca_CA |
dc.subject | epilepsy | ca_CA |
dc.subject | kainate | ca_CA |
dc.subject | DHA | ca_CA |
dc.subject | PUFA | ca_CA |
dc.subject | pre-spawning | ca_CA |
dc.subject | aging | ca_CA |
dc.title | Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.brainresbull.2012.04.007 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S0361923012000780 | ca_CA |
dc.description.sponsorship | This work was funded by the financial resources of Neuron Bio and supported by grants from the Agencia de Innovación y Desarrollo de Andalucía of the Junta de Andalucía and from the CDTI of the Ministerio de Ciencia e Innovación (AL-ANSALUD project), and by funds from the Torres Quevedo program (Sierra S, Alfaro J.M. and Burgos J.S.). | |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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