Bactericidal activity of Ag4V2O7/β-AgVO3 heterostructures against antibiotic-resistant Klebsiella pneumoniae
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comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
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INVESTIGACIONMetadata
Title
Bactericidal activity of Ag4V2O7/β-AgVO3 heterostructures against antibiotic-resistant Klebsiella pneumoniaeAuthor (s)
Date
2022-10Publisher
ElsevierISSN
2772-9508Bibliographic citation
Assis M, da Silva JS, Gonçalves MO, de Almeida Rodolpho JM, de Lima Fragelli BD, Corte ABP, Ribeiro LK, Teodoro MD, de Freitas Anibal F, de Sousa CP, Oliveira ON Jr, Andrés J, Longo E. Bactericidal activity of Ag4V2O7/β-AgVO3 heterostructures against antibiotic-resistant Klebsiella pneumoniae. Biomater Adv., 141 (2022). doi: 10.1016/j.bioadv.2022.213097Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S2772950822003740Subject
Abstract
Although Ag-based materials are efficient against antibiotic-resistant bacteria, their high toxicity to living organisms represents a major challenge for obtaining useful products. In this work, we report the bacter ... [+]
Although Ag-based materials are efficient against antibiotic-resistant bacteria, their high toxicity to living organisms represents a major challenge for obtaining useful products. In this work, we report the bactericidal activity of Ag4V2O7/β-AgVO3 heterostructures, which proved to be effective against Klebsiella pneumoniae (ATCC 1706, a standard strain; A54970, a multidrug-resistant carbapenemase (KPC)-producing strain; A34057, a multidrug-resistant strain capable of producing extended spectrum beta-lactamases (ESBL); and a community-isolated strain, A58240) at minimum inhibitory concentrations (MIC) as low as 62.5 μg/mL. This activity is higher than that reported for the individual silver vanadates (Ag4V2O7 or β-AgVO3) owing to the synergistic interactions between both semiconductors. However, the most efficient heterostructure was found to be toxic to mouse 3 T3 fibroblasts and to L. sativa and C. sativus seeds, as indicated by MTT ((4,5 - dimethylthiazol -2yl) 2,5 -diphenylbromide), neutral red assays and germination index measurements. The antimicrobial, phytotoxic and cytotoxic activities were all associated with an efficient generation of reactive oxygen species (ROS) in the heterostructure, especially radical dotOH and radical dotO2− radicals. The ROS production by Ag4V2O7/β-AgVO3 heterostructures was measured through photodegradation studies with Rhodamine B. While the bactericidal activity of the heterostructures is promising, especially when compared to Ag-based materials, their use in practical applications will require encapsulation either to avoid leaching or to mitigate their toxicity to humans, animals and plants. [-]
Is part of
Biomaterials Advances, 2022, vol. 141Funder Name
Universitat Jaume I | Ministerio de Ciencia, Innovación y Universidades | European Union-Next Generation | PETROBRAS | Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP | Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq
Funder ID
http://dx.doi.org/10.13039/501100011033
Project code
UJI-B2019-30 | MICIU/ICTI2017-2020/ PGC2018-094417-B-I00 | UP2021-021 | 2017/00010-7 | 2013/07296-2 | 2016/13423-5 | 2018/22214-6 | 141964/2018-9
Project title or grant
Aproximaciones racionales para el diseño de nuevos materiales mediante la combinación de teoría y experimento
Rights
info:eu-repo/semantics/openAccess
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