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Anti-SARS-CoV-2 IgA and IgG in human milk after vaccination is dependent on vaccine type and previous SARS-CoV-2 exposure: a longitudinal study
dc.contributor.author | Selma Royo, Marta | |
dc.contributor.author | Bäuerl, Christine | |
dc.contributor.author | Mena Tudela, Desirée | |
dc.contributor.author | Aguilar-Camprubí, Laia | |
dc.contributor.author | Pérez-Cano, Francisco J | |
dc.contributor.author | PARRA LLORCA, ANNA | |
dc.contributor.author | Lerin, Carles | |
dc.contributor.author | Martinez-Costa, Cecilia | |
dc.contributor.author | COLLADO, MARIA CARMEN | |
dc.date.accessioned | 2022-06-08T14:23:04Z | |
dc.date.available | 2022-06-08T14:23:04Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Selma-Royo, M., Bäuerl, C., Mena-Tudela, D. et al. Anti-SARS-CoV-2 IgA and IgG in human milk after vaccination is dependent on vaccine type and previous SARS-CoV-2 exposure: a longitudinal study. Genome Med 14, 42 (2022). https://doi.org/10.1186/s13073-022-01043-9 | ca_CA |
dc.identifier.issn | 1756-994X | |
dc.identifier.uri | http://hdl.handle.net/10234/197949 | |
dc.description.abstract | Background Breast milk is a vehicle to transfer protective antibodies from the lactating mother to the neonate. After SARS-CoV-2 infection, virus-specific IgA and IgG have been identified in breast milk, however, there are limited data on the impact of different COVID-19 vaccine types in lactating women. This study is aimed to evaluate the time course of induction of SARS-CoV-2-specific IgA and IgG in breast milk after vaccination. Methods In this prospective observational study in Spain, 86 lactating women from priority groups receiving the vaccination against SARS-CoV-2 were included. Breast milk samples were collected longitudinally at seven or eight-time points (depending on vaccine type). A group with confirmed SARS-CoV-2 infection (n=19) and a group of women from pre-pandemic time (n=20) were included for comparison. Results Eighty-six vaccinated lactating women [mean age, 34.6 ± 3.7 years] of whom 96% were Caucasian and 92% were healthcare workers. A total number of 582 milk samples were included, and vaccine distribution was BioNTech/Pfizer (BNT162b2, n=34), Moderna (mRNA-1273, n=20), and AstraZeneca (ChAdOx1 nCoV-19, n=32). For each vaccine, 7 and 8 longitudinal time points were collected from baseline up to 30 days after the second dose for mRNA vaccines and adenovirus-vectored vaccines, respectively. A strong reactivity was observed for IgG and IgA after vaccination mainly after the 2nd dose. The presence and persistence of specific SARS-CoV-2 antibodies in breast milk were dependent on the vaccine type, with higher IgG and IgA levels in mRNA-based vaccines when compared to AstraZeneca, and on previous virus exposure. High intra- and inter-variability were observed, being relevant for IgA antibodies. In milk from vaccinated women, anti-SARS-CoV-2 IgG was significantly higher while IgA levels were lower than in milk from COVID-19-infected women. Women with previous COVID-19 increased their IgG antibodies levels after the first dose to a similar level observed in vaccinated women after the second dose. Conclusions COVID-19 vaccination induced anti-SARS-CoV-2 IgA and IgG in breast milk with higher levels after the 2nd dose. Levels of anti-SARS-CoV-2 IgA and IgG are dependent on the vaccine type. Further studies are warranted to demonstrate the protective antibody effect against COVID-19 in infants from vaccinated and infected mothers. | ca_CA |
dc.format.extent | 11 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | BMC | ca_CA |
dc.relation.isPartOf | Genome medicine, 2022, 14.1: 1-11. | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.subject | breast milk | ca_CA |
dc.subject | SARS-CoV-2 | ca_CA |
dc.subject | antibodies | ca_CA |
dc.subject | immunoglobulins | ca_CA |
dc.subject | vaccines | ca_CA |
dc.title | Anti-SARS-CoV-2 IgA and IgG in human milk after vaccination is dependent on vaccine type and previous SARS-CoV-2 exposure: a longitudinal study | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1186/s13073-022-01043-9 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | LaMarató-TV3 | ca_CA |
oaire.awardNumber | MilkCORONA, ref. 202106 | ca_CA |
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