Ultrastructural characterization of human oligodendrocytes and their progenitor cells by pre-embedding immunogold
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
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Título
Ultrastructural characterization of human oligodendrocytes and their progenitor cells by pre-embedding immunogoldAutoría
Fecha de publicación
2021Editor
Frontiers MediaISSN
1662-5129Cita bibliográfica
Ulloa-Navas MJ, Pérez-Borredá P, Morales-Gallel R, Saurí-Tamarit A, García-Tárraga P, Gutiérrez-Martín AJ, Herranz-Pérez V and García-Verdugo JM (2021) Ultrastructural Characterization of Human Oligodendrocytes and Their Progenitor Cells by Pre-embedding Immunogold. Front. Neuroanat. 15:696376. doi: 10.3389/fnana.2021.696376Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Oligodendrocytes are the myelinating cells of the central nervous system. They provide
trophic, metabolic, and structural support to neurons. In several pathologies such as
multiple sclerosis (MS), these cells are ... [+]
Oligodendrocytes are the myelinating cells of the central nervous system. They provide
trophic, metabolic, and structural support to neurons. In several pathologies such as
multiple sclerosis (MS), these cells are severely affected and fail to remyelinate, thereby
leading to neuronal death. The gold standard for studying remyelination is the g-ratio,
which is measured by means of transmission electron microscopy (TEM). Therefore,
studying the fine structure of the oligodendrocyte population in the human brain at
different stages through TEM is a key feature in this field of study. Here we study the
ultrastructure of oligodendrocytes, its progenitors, and myelin in 10 samples of human
white matter using nine different markers of the oligodendrocyte lineage (NG2, PDGFRα,
A2B5, Sox10, Olig2, BCAS1, APC-(CC1), MAG, and MBP). Our findings show that
human oligodendrocytes constitute a very heterogeneous population within the human
white matter and that its stages of differentiation present characteristic features that can
be used to identify them by TEM. This study sheds light on how these cells interact with
other cells within the human brain and clarify their fine characteristics from other glial cell
types. [-]
Publicado en
Frontiers in Neuroanatomy 15:696376Entidad financiadora
Ministry of Science, Innovation, and Universities (Spain) | Red deTerapia Celular | Valencian Council for Innovation, Universities Science and Digital Society
Código del proyecto o subvención
PCI2018-093062 | TerCel-RD16/0011/0026 | PROMETEO/2019/075
Título del proyecto o subvención
Nano-scaffolding for neuronal migration and generation
Derechos de acceso
info:eu-repo/semantics/openAccess
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