Neurotrophic factors and brain health in children with overweight and obesity: the role of cardiorespiratory fitness
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Other documents of the author: Adelantado-Renau, Mireia; Esteban-Cornejo, Irene; Mora-Gonzalez, Jose; Plaza Florido, Abel Adrian; Rodriguez-Ayllon, María; Maldonado Lozano, Jose; Escolano Margarit, Maria Victoria; Gómez Vida, José; Catena, Andres; Erickson, Kirk; Ortega, Francisco B
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/174799
comunitat-uji-handle3:10234/174800
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Title
Neurotrophic factors and brain health in children with overweight and obesity: the role of cardiorespiratory fitnessAuthor (s)
Date
2022-03-06Publisher
Taylor & FrancisISSN
1536-7290; 1746-1391Bibliographic citation
Mireia Adelantado-Renau, Irene Esteban-Cornejo, Jose Mora-Gonzalez, Abel Plaza-Florido, María Rodriguez-Ayllon, José Maldonado, M. Victoria Escolano-Margarit, José Gómez Vida, Andres Catena-Martinez, Kirk I. Erickson & Francisco B. Ortega (2022) Neurotrophic factors and brain health in children with overweight and obesity: The role of cardiorespiratory fitness, European Journal of Sport ScienceType
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/acceptedVersionSubject
Abstract
Neurotrophic factors and cardiorespiratory fitness are both considered important in developmental trajectories but their link to brain health remains poorly understood. The aims of the study were to examine whether ... [+]
Neurotrophic factors and cardiorespiratory fitness are both considered important in developmental trajectories but their link to brain health remains poorly understood. The aims of the study were to examine whether levels of plasma-derived neurotrophic factors were associated with brain health indicators in children with overweight or obesity; and to test whether these associations were moderated by cardiorespiratory fitness. 100 children (41% girls) were included in this analysis. Plasma levels of brain-derived neurotrophic factor, insulin-like growth factor-1, vascular endothelial growth factor A, and epidermal growth factor were determined by XMap technology. Academic performance and executive function were assessed using validated neuropsychological tests. Hippocampal volume was measured using magnetic resonance imaging. Cardiorespiratory fitness was assessed using the 20-m Shuttle Run Test. Insulin-like growth factor-1 was positively associated with cognitive flexibility. Stratified analyses by fitness categories (i.e. unfit vs. fit) showed that brain-derived neurotrophic factor was positively associated with right posterior hippocampal volume in fit children, and epidermal growth factor was negatively associated with right hippocampal, and right anterior hippocampal volumes in their unfit peers, with a moderating role of cardiorespiratory fitness in these associations. However, all these significant associations disappeared after correction for multiple comparisons. The association between neurotrophic factors and brain health indicators in children with overweight/obesity was neither strong nor consistent. These results could help enhance our understanding of determinants of brain health in children with overweight/obesity. [-]
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European Journal of Sport Science, Volume 22 (2022)Funder Name
Spanish Ministry of Economy and Competitiveness | EXERNET Research Network on Exercise and Health in Special Populations | Spanish Ministry of Education, Culture and Sport
Project code
DEP2013-47540 / DEP2016-79512-R / DEP2017-91544-EXP / RTI2018-095284-J-100 | DEP2005-00046/ACTI | FPU 16/02760
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info:eu-repo/semantics/openAccess
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