Human Milk Antioxidative Modifications in Mastitis: Further Beneficial Effects of Cranberry Supplementation
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Títol
Human Milk Antioxidative Modifications in Mastitis: Further Beneficial Effects of Cranberry SupplementationAutoria
Data de publicació
2022Editor
MDPIISSN
2076-3921Cita bibliogràfica
Valls-Bellés, V.; Abad, C.; Hernández-Aguilar, M.T.; Nacher, A.; Guerrero, C.; Baliño, P.; Romero, F.J.; Muriach, M. Human Milk Antioxidative Modifications in Mastitis: Further Beneficial Effects of Cranberry Supplementation. Antioxidants 2022, 11, 51.Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Mastitis is the inflammation of one or several mammal lobes which can be accompanied by a
mammary gland infection, and is the leading cause of undesired early weaning in humans. However,
little information exists ... [+]
Mastitis is the inflammation of one or several mammal lobes which can be accompanied by a
mammary gland infection, and is the leading cause of undesired early weaning in humans. However,
little information exists regarding the changes that this disease may induce in the biochemical
composition of human milk, especially in terms of oxidative status. Given that newborns are
subject to a significant increase in total ROS burden in their transition to neonatal life and that
their antioxidant defense system is not completely developed, the aim of this study was to evaluate
antioxidant defense (glutathione peroxidase (GPx), reduced glutathione (GSH), total polyphenol
content (TPP), and total antioxidant capacity (TAC)) in milk samples from mothers suffering from
mastitis and controls. We also measured the oxidative damage to lipids (malondyaldehyde (MDA))
and proteins (carbonyl group content (CGC)) in these samples. Finally, we tested whether dietary
supplementation with cranberries (a product rich in antioxidants) in these breastfeeding mothers
during 21 days could improve the oxidative status of milk. GPx activity, TPP, and TAC were increased
in milk samples from mastitis-affected women, providing a protective mechanism to the newborn
drinking mastitis milk. MDA concentrations were diminished in the mastitis group, confirming this
proposal. Some oxidative damage might occur in the mammary gland since the CGC was increased
in mastitis milk. Cranberries supplementation seems to strengthen the antioxidant system, further
improving the antioxidative state of milk. [-]
Publicat a
Antioxidants 2022, 11, 51Entitat finançadora
Universitat Jaume I de Castellón
Codi del projecte o subvenció
UJI-A2016-03 | UJI-B2019-38
Drets d'accés
info:eu-repo/semantics/openAccess
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