“Skills for pills”: The dialectical-behavioural therapy skills training reduces polypharmacy in borderline personality disorder
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comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Title
“Skills for pills”: The dialectical-behavioural therapy skills training reduces polypharmacy in borderline personality disorderAuthor (s)
Date
2022-04Publisher
WileyISSN
0001-690X; 1600-0447Bibliographic citation
Soler J, Casellas-Pujol E, Fernández-Felipe I, Martín-Blanco A, Almenta D, Pascual JC. “Skills for pills”: The dialecticalbehavioural therapy skills training reduces polypharmacy in borderline personality disorder. Acta Psychiatr Scand. 2022;145:332–342. doi:10.1111/ acps.13403Type
info:eu-repo/semantics/articlePublisher version
https://onlinelibrary.wiley.com/doi/full/10.1111/acps.13403Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Objective:
Polypharmacy and overprescription of off-label medications are common in patients with borderline personality disorder (BPD). The aim of the present naturalistic study was to explore whether the skills ... [+]
Objective:
Polypharmacy and overprescription of off-label medications are common in patients with borderline personality disorder (BPD). The aim of the present naturalistic study was to explore whether the skills training module of dialectical-behavioural therapy (DBT) can reduce polypharmacy in these patients in routine clinical practice.
Methods:
Retrospective, observational study of 377 patients with a primary diagnosis of BPD consecutively admitted to the BPD outpatient unit from 2010 through 2020. All patients were invited to participate in the DBT skills training module (DBT-ST). DBT-ST participants (n = 182) were compared with a control group who did not participate in DBT-ST (n = 195). Pre-post intervention changes in medication load and use of antidepressants, benzodiazepines, mood stabilizers, and antipsychotics were evaluated.
Results:
At baseline, most patients (84.4%) were taking at least one medication and 46.9% were on polypharmacy. Compared to controls, patients in the DBT-ST group presented a significant reduction in the number of medications (2.67–1.95 vs. 2.16–2.19; p < 0.001), medication load (4.25–3.05 vs. 3.45–3.48; p < 0.001), use of benzodiazepines (54.4%–27.5% vs. 40%–40.5%; p < 0.001), mood stabilizers (43.4%–33% vs. 36.4%–39.5%; p < 0.001), and antipsychotics (36.3%–29.1% vs. 34.4%–36.9%; p < 0.001).
Conclusions:
These findings suggest that patients with BPD can benefit from the DBT-ST module, which may reduce the medication load, particularly of sedatives. The results suggest that DBT-ST may be useful to treat overmedication in patients with BPD and could help to promote “deprescription” in clinical practice. [-]
Is part of
Acta Psychiatrica Scandinavica, 2022, vol. 145, no 4Funder Name
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
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info:eu-repo/semantics/openAccess
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- PSB_Articles [1321]