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Distance disintegration characterizes node-level topological dysfunctions in cocaine addiction
dc.contributor.author | Costumero, Víctor | |
dc.contributor.author | Rosell Negre, Patricia | |
dc.contributor.author | Bustamante, Juan Carlos | |
dc.contributor.author | Fuentes-Claramonte, Paola | |
dc.contributor.author | Adrián-Ventura, Jesús | |
dc.contributor.author | Palomar-García, María-Ángeles | |
dc.contributor.author | Miró-Padilla, Anna | |
dc.contributor.author | Llopis, Juan José | |
dc.contributor.author | Sepulcre, Jorge | |
dc.contributor.author | Barrós-Loscertales, Alfonso | |
dc.date.accessioned | 2021-12-20T10:29:13Z | |
dc.date.available | 2021-12-20T10:29:13Z | |
dc.date.issued | 2021-11 | |
dc.identifier.citation | Costumero, V, Rosell Negre, P, Bustamante, JC, et al. Distance disintegration characterizes node-level topological dysfunctions in cocaine addiction. Addiction Biology. 2021; 26( 6):e13072. https://doi.org/10.1111/adb.13072 | ca_CA |
dc.identifier.issn | 1355-6215 | |
dc.identifier.issn | 1369-1600 | |
dc.identifier.uri | http://hdl.handle.net/10234/196258 | |
dc.description.abstract | Previous investigations have used global graph theory measures in order to disentangle the complexity of the neural reorganizations occurring in cocaine use disorder (CUD). However, how these global topological alterations map into individual brain network areas remains unknown. In this study, we used resting state functional magnetic resonance imaging (fMRI) data to investigate node-level topological dysfunctions in CUD. The sample was composed of 32 individuals with CUD and 32 healthy controls, matched in age, years of education and intellectual functioning. Graph theory measures of optimal connectivity distance, node strength, nodal efficiency and clustering coefficient were estimated in each participant using voxel-wise functional connectivity connectomes. CUD individuals as compared with healthy controls showed higher optimal connectivity distances in ventral striatum, insula, cerebellum, temporal cortex, lateral orbitofrontal cortex, middle frontal cortex and left hippocampus. Furthermore, clinical measures quantifying severity of dependence were positively related with optimal connectivity distances in the right rolandic operculum and the right lateral orbitofrontal cortex, whereas length of abstinence was negatively associated with optimal connectivity distances in the right temporal pole and the left insula. Our results reveal a topological distancing of cognitive and affective related areas in addiction, suggesting an overall reduction in the communication capacity of these regions. | ca_CA |
dc.description.sponsorShip | Funding for open access charge: CRUE-Universitat Jaume I | |
dc.format.extent | 10 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Wiley | ca_CA |
dc.relation.isPartOf | Addiction biology, 2021, vol. 26, no 6 | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | ca_CA |
dc.subject | addiction | ca_CA |
dc.subject | cocaine | ca_CA |
dc.subject | functional connectivity | ca_CA |
dc.subject | graph theory | ca_CA |
dc.subject | optimal connectivity distance | ca_CA |
dc.subject | resting state | ca_CA |
dc.title | Distance disintegration characterizes node-level topological dysfunctions in cocaine addiction | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1111/adb.13072 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://onlinelibrary.wiley.com/doi/full/10.1111/adb.13072 | ca_CA |
dc.description.sponsorship | This research was supported by grant 040/2011 from Spanish National Drug Strategy, Ministerio de Sanidad y Consumo to ABL. JAV was supported by a predoctoral graduate programme grant (National FPU). MPG and AMP were supported by a postdoctoral graduate programme grant (postdoc-UJI). VC was supported by grant PID2019-105077RJ-I00 from Ministerio de Ciencia, Innovación y Universidades. | |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Ministerio de Ciencia, Innovación y Universidades | ca_CA |
project.funder.name | Ministerio de Sanidad y Consumo | ca_CA |
oaire.awardNumber | PID2019-105077RJ-I00 | ca_CA |
oaire.awardNumber | 040/2011 | ca_CA |
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