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dc.contributor.authorCerqueira, Andreia
dc.contributor.authorAraújo-Gomes, Nuno
dc.contributor.authorZhang, Yang
dc.contributor.authorvan den Beucken, Jeroen
dc.contributor.authorMartínez Ramos, Cristina
dc.contributor.authorozturan, seda
dc.contributor.authorIzquierdo Escrig, Raul
dc.contributor.authorMuriach, Maria
dc.contributor.authorRomero Cano, Ricard
dc.contributor.authorBaliño, Pablo
dc.contributor.authorRomero-Gavilán, Francisco J
dc.date.accessioned2021-09-15T07:55:25Z
dc.date.available2021-09-15T07:55:25Z
dc.date.issued2021-02-20
dc.identifier.citationCerqueira A, Araújo-Gomes N,Zhang Y, et al. Evaluation of the inflammatory responses tosol–gel coatings with distinct biocompatibility levels. J BiomedMater Res. 2021;109:1539–1548.https://doi.org/10.1002/jbm.a.371491548ca_CA
dc.identifier.issn1549-3296
dc.identifier.issn1552-4965
dc.identifier.urihttp://hdl.handle.net/10234/194712
dc.description.abstractThe immune system plays a crucial role in determining the implantation outcome, and macrophages are in the frontline of the inflammatory processes. Further, cellular oxidative stress resulting from the material recognition can influence how cell responses develop. Considering this, the aim of this study was to study oxidative stress and macrophages phenotypes in response to sol–gel materials with distinct in vivo outcomes. Four materials were selected (70M30T and 35M35G30T, with high biocompatibility, and 50M50G and 50V50G, with low biocompatibility). Gene expression, immunocytochemistry and cytokine secretion profiles for M1 and M2 markers were determined. Moreover, oxidative stress markers were studied. Immunocytochemistry and ELISA showed that 50M50G and 50V50G lead to a higher differentiation to M1 phenotype, while 70M30T and 35M35G30T promoted M2 differentiation. In oxidative stress, no differences were found. These results show that the balance between M1 and M2, more than individual quantification of each phenotype, determines a biomaterial outcome.ca_CA
dc.format.extent24 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherJohn Wiley and Sonsca_CA
dc.publisherWileyca_CA
dc.publisherWiley Periodicalsca_CA
dc.publisherSociety For Biomaterials (USA)ca_CA
dc.publisherJapanese Society for Biomaterialsca_CA
dc.publisherAustralasian Society for Biomaterialsca_CA
dc.publisherKorean Society for Biomaterialsca_CA
dc.relation.isPartOfJ Biomed Mater Res. 2021;109:1539–1548.ca_CA
dc.relation.urihttps://onlinelibrary.wiley.com/action/downloadFigures?id=jbma37149-fig-0002&doi=10.1002%2Fjbm.a.37149ca_CA
dc.rights© 2021 Wiley Periodicals LLCca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/ca_CA
dc.subjectbiomaterialsca_CA
dc.subjectimplantsca_CA
dc.subjectinflammationca_CA
dc.subjectmacrophage plasticityca_CA
dc.subjectoxidative markersca_CA
dc.titleEvaluation of the inflammatory responses to sol–gel coatingswith distinct biocompatibility levelsca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1002/jbm.a.37149
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://onlinelibrary.wiley.com/journal/15524965ca_CA
dc.type.versioninfo:eu-repo/semantics/acceptedVersionca_CA
project.funder.nameGeneralitat Valencianaca_CA
project.funder.nameMinisterio de Economía y Competitividadca_CA
project.funder.nameUniversitat Jaume Ica_CA
oaire.awardNumberGRISOLIAP/2018/091ca_CA
oaire.awardNumberMAT2017-86043-Rca_CA
oaire.awardNumberRTC-2017-6147-1ca_CA
oaire.awardNumberPOSDOC/2019/28ca_CA


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