Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose Bengal
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Otros documentos de la autoría: Gavara, Raquel; de Llanos Frutos, Rosa; Pérez Laguna, Vanesa; Arnau del Valle, Carla; Miravet, Juan; Rezusta López, Antonio; Galindo, Francisco
Metadatos
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INVESTIGACIONMetadatos
Título
Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose BengalAutoría
Fecha de publicación
2021-05-24Editor
Frontiers MediaISSN
2296-858XCita bibliográfica
Gavara R, de Llanos R, Pérez-Laguna V, Arnau del Valle C, Miravet JF, Rezusta A and Galindo F (2021) Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose Bengal. Front. Med. 8:641646. doi: 10.3389/fmed.2021.641646Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
New strategies to fight bacteria and fungi are necessary in view of the problem of iatrogenic and nosocomial infections combined with the growing threat of increased antimicrobial resistance. Recently, our group has ... [+]
New strategies to fight bacteria and fungi are necessary in view of the problem of iatrogenic and nosocomial infections combined with the growing threat of increased antimicrobial resistance. Recently, our group has prepared and described two new readily available materials based on the combination of Rose Bengal (singlet oxygen photosensitizer) and commercially available cationic polystyrene (macroporous resin Amberlite® IRA 900 or gel-type resin IRA 400). These materials showed high efficacy in the antimicrobial photodynamic inactivation (aPDI) of Pseudomonas aeruginosa. Here, we present the photobactericidal effect of these polymers against an extended group of pathogens like Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and the opportunistic yeast Candida albicans using green light. The most interesting finding is that the studied materials are able to reduce the population of both Gram-positive and Gram-negative bacteria with good activity, although, for C. albicans, in a moderate manner. In view of the results achieved and especially considering the inexpensiveness of these two types of photoactive polymers, we believe that they could be used as the starting point for the development of coatings for self-disinfecting surfaces. [-]
Publicado en
Frontiers in Medicine 8:641646Entidad financiadora
Universitat Jaume I | Aragón Government: Infectious Diseases of Difficult Diagnosis and Treatment research group | Universitat Jaume I
Código del proyecto o subvención
UJI-B2018-30 | GIIS-023 | POSDOC-B/2018/09
Derechos de acceso
info:eu-repo/semantics/openAccess
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