Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose Bengal
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Altres documents de l'autoria: Gavara, Raquel; de Llanos Frutos, Rosa; Pérez Laguna, Vanesa; Arnau del Valle, Carla; Miravet, Juan; Rezusta López, Antonio; Galindo, Francisco
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INVESTIGACIONMetadades
Títol
Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose BengalAutoria
Data de publicació
2021-05-24Editor
Frontiers MediaISSN
2296-858XCita bibliogràfica
Gavara R, de Llanos R, Pérez-Laguna V, Arnau del Valle C, Miravet JF, Rezusta A and Galindo F (2021) Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose Bengal. Front. Med. 8:641646. doi: 10.3389/fmed.2021.641646Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
New strategies to fight bacteria and fungi are necessary in view of the problem of iatrogenic and nosocomial infections combined with the growing threat of increased antimicrobial resistance. Recently, our group has ... [+]
New strategies to fight bacteria and fungi are necessary in view of the problem of iatrogenic and nosocomial infections combined with the growing threat of increased antimicrobial resistance. Recently, our group has prepared and described two new readily available materials based on the combination of Rose Bengal (singlet oxygen photosensitizer) and commercially available cationic polystyrene (macroporous resin Amberlite® IRA 900 or gel-type resin IRA 400). These materials showed high efficacy in the antimicrobial photodynamic inactivation (aPDI) of Pseudomonas aeruginosa. Here, we present the photobactericidal effect of these polymers against an extended group of pathogens like Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and the opportunistic yeast Candida albicans using green light. The most interesting finding is that the studied materials are able to reduce the population of both Gram-positive and Gram-negative bacteria with good activity, although, for C. albicans, in a moderate manner. In view of the results achieved and especially considering the inexpensiveness of these two types of photoactive polymers, we believe that they could be used as the starting point for the development of coatings for self-disinfecting surfaces. [-]
Publicat a
Frontiers in Medicine 8:641646Entitat finançadora
Universitat Jaume I | Aragón Government: Infectious Diseases of Difficult Diagnosis and Treatment research group | Universitat Jaume I
Codi del projecte o subvenció
UJI-B2018-30 | GIIS-023 | POSDOC-B/2018/09
Drets d'accés
info:eu-repo/semantics/openAccess
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