Psychologic Treatment of Depression Compared With Pharmacotherapy and Combined Treatment in Primary Care: A Network Meta-Analysis
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Scholar |
Otros documentos de la autoría: Cuijpers, Pim; Oud, Matthijs; Karyotaki, Eirini; Noma, Hisashi; Quero, Soledad; Cipriani, Andrea; arroll, bruce; Furukawa, Toshi
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
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INVESTIGACIONMetadatos
Título
Psychologic Treatment of Depression Compared With Pharmacotherapy and Combined Treatment in Primary Care: A Network Meta-AnalysisAutoría
Fecha de publicación
2021-05Editor
Annals of Family MedicineDOI
10.1370/afm.2676ISSN
1544-1709Cita bibliográfica
Cuijpers, P., Oud, M., Karyotaki, E., Noma, H., Quero, S., Cipriani, A., ... & Furukawa, T. A. (2021). Psychologic Treatment of Depression Compared With Pharmacotherapy and Combined Treatment in Primary Care: A Network Meta-Analysis. The Annals of Family Medicine, 19(3), 262-270.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.annfammed.org/content/19/3/262Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
PURPOSE Most patients with depression are treated by general practitioners, and most of those patients prefer psychotherapy over pharmacotherapy. No network meta-analyses have examined the effects of psychotherapy ... [+]
PURPOSE Most patients with depression are treated by general practitioners, and most of those patients prefer psychotherapy over pharmacotherapy. No network meta-analyses have examined the effects of psychotherapy compared with pharmacotherapy, combined treatment, care as usual, and other control conditions among patients in primary care.
METHODS We conducted systematic searches of bibliographic databases to identify randomized trials comparing psychotherapy with pharmacotherapy, combined treatment, care as usual, waitlist, and pill placebo. The main outcome was treatment response (50% improvement of depressive symptoms from baseline to end point).
RESULTS A total of 58 studies with 9,301 patients were included. Both psychotherapy and pharmacotherapy were significantly more effective than care as usual (relative risk [RR] for response = 1.60; 95% CI, 1.40-1.83 and RR = 1.65; 95% CI, 1.35-2.03, respectively) and waitlist (RR = 2.35; 95% CI, 1.57-3.51 and RR = 2.43; 95% CI, 1.57-3.74, respectively) control groups. We found no significant differences between psychotherapy and pharmacotherapy (RR = 1.03; 95% CI, 0.88-1.22). The effects were significantly greater for combined treatment compared with psychotherapy alone (RR = 1.35; 95% CI, 1.00-1.81). The difference between combined treatment and pharmacotherapy became significant when limited to studies with low risk of bias and studies limited to cognitive behavior therapy.
CONCLUSIONS Psychotherapy is likely effective for the treatment of depression when compared with care as usual or waitlist, with effects comparable to those of pharmacotherapy. Combined treatment might be better than either psychotherapy or pharmacotherapy alone. [-]
Entidad financiadora
National Institute for Health Research (NIHR) Oxford Cognitive Health Clinical Research Facility; an NIHR Research Professorship | NIHR Oxford and Thames Valley Applied Research Collaboration; and the NIHR Oxford Health Biomedical Research Centre | CIBERObn, an initiative of the ISCIII
Código del proyecto o subvención
RP-2017-08-ST2-006 | BRC-1215-20005 | ISCIII CB06 03/0052
Derechos de acceso
info:eu-repo/semantics/openAccess
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