Methods for the determination of selective androgenic beta-blockers in biological samples
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Título
Methods for the determination of selective androgenic beta-blockers in biological samplesAutoría
Tutor/Supervisor; Universidad.Departamento
Esteve-Romero, Josep; Sancho Llopis, Juan Vicente; Universitat Jaume I. Departament de Química Física i AnalíticaFecha de publicación
2020-07-24Editor
Universitat Jaume IResumen
Medications are an important part of our daily lives, and androgenic beta-blockers represent
an important part of these. They are used all over the world to treat various diseases, mainly
heart diseases.
In this ... [+]
Medications are an important part of our daily lives, and androgenic beta-blockers represent
an important part of these. They are used all over the world to treat various diseases, mainly
heart diseases.
In this work we review the obtaining of the first beta blockers together with their evolution,
the mechanism of action in the main site of action, the pharmacological effects produced,
their pharmacokinetics and their side effects.
The current methods of analysis for the determination of beta blockers are also described,
specifically the selective ones, both the preparation of the sample by SPE, SPME, LLE; and its
analysis by HPLC, Mis-LC, CE, GC-MS, LC-MS.
All these methods have given satisfactory results for the analysis of selective beta blockers in
biological samples. According to the data collected in this work, it can be considered that in
the future, the analysis of selective beta blockers in low concentrations (ng or pg) will be
performed by using HPLC-MS and MLC.
The main objectives of this study are to report on selective beta blockers and their analysis
methods at present. [-]
Palabras clave / Materias
Descripción
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2019/2020
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- Grau en Química [265]