Study of pharmaceutical determination in water by solid phase extraction followed by liquid chromatography-mass spectrometry
Metadatos
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Metadatos
Título
Study of pharmaceutical determination in water by solid phase extraction followed by liquid chromatography-mass spectrometryAutoría
Tutor/Supervisor; Universidad.Departamento
Pitarch, Elena; Sancho Llopis, Juan Vicente; Universitat Jaume I. Departament de Química Física i AnalíticaFecha de publicación
2020-07-24Editor
Universitat Jaume IResumen
An analytical method has been studied for the determination of selected pharmaceuticals in
different water samples by liquid chromatography coupled to tandem mass spectrometry (LCMS/MS). Samples studied were 9 in ... [+]
An analytical method has been studied for the determination of selected pharmaceuticals in
different water samples by liquid chromatography coupled to tandem mass spectrometry (LCMS/MS). Samples studied were 9 in total from different types(two surface water, three effluents
and four influents wastewater) coming from various locations in Spain. The studied
pharmaceuticals included eight antibiotics, an analgesic, an antidepressant, a hypolipidemic
agent, two antihypertensive, an antiepileptic, an anti-inflammatory, and one anthelmintic agent.
The study consisted in the investigation of the quality control (QCs) prepared from selected
samples fortified at 500 ng/mL for surface an effluent wastewater and 100 ng/mL for influent
wastewater. A prior solid phase extraction (SPE) was performed using Oasis HLB (150 mg)
cartridges. The corresponding isotopically- labelled internal standards (ILIS) were added before
extraction. The analytical determination was performed by LC-MS/MS using a triple quadrupole
analyser and three MS/MS transitions were acquired for each analyte for a reliable confirmation.
The matrix effect was evaluated from the experiences performed by ILIS. The results were
satisfactory for the surface water samples, for the rest of the samples this effect was higher. The
extraction process was evaluated in terms of accuracy and precision using the corresponding
ILIS for correction. Recoveries of the 16 selected pharmaceuticals were in general satisfactory
(between 70-120%) for all types of water samples studied, with the exceptions of some drugs in
effluent wastewater such as Trimethoprim, with results higher in influent wastewater for
instance: Norfloxacin, Ciprofloxacin and Acetaminophen. Relative standard deviations (RSDs)
were lower than 20% for the majority of compounds with two exceptions Valsartan and
Sulfamethoxazole in one type of water. [-]
Palabras clave / Materias
Descripción
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2019/2020
Tipo de documento
info:eu-repo/semantics/bachelorThesisDerechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
Aparece en las colecciones
- Grau en Química [265]