Recent developments about determination of non-selective adrenergic beta blockers in physiological samples
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Title
Recent developments about determination of non-selective adrenergic beta blockers in physiological samplesAuthor (s)
Tutor/Supervisor; University.Department
Esteve-Romero, Josep; Sancho Llopis, Juan Vicente; Universitat Jaume I. Departament de Química Física i AnalíticaDate
2020-07-24Publisher
Universitat Jaume IAbstract
Beta adrenergic blockers represent a very important class of drugs that are used worldwide for
treating various disorders, usually cardiac diseases. Also, these class of drugs are usually used
as a doping agent. For ... [+]
Beta adrenergic blockers represent a very important class of drugs that are used worldwide for
treating various disorders, usually cardiac diseases. Also, these class of drugs are usually used
as a doping agent. For these reasons, in this work are described history of beta blockers, its
mechanism of action, pharmacological and side effects, and pharmacokinetics. In addition to,
it describes actual state of analysis of these drugs using the most important sample preparation
and analysis techniques. Sample preparation techniques, for example liquid-liquid extraction,
solid-phase extraction, and solid-phase microextraction have been discussed. Sample
preparation is essential to some methods of analysis as High-performance liquid
chromatography (HPLC) and it is coupling with mass spectroscopy (MS), because they have
not direct injection. Additionally, other methods of analysis have been studied as Micellar
liquid chromatography (MLC), capillary electrophoresis (CE), and gas chromatography-mass
spectrometry (GC-MS). It has been observed that the reported methods are quite satisfactory
for the analyses of beta blockers in physiological samples. Future perspectives in the analysis
of beta blockers is the use of HPLC with MS and MLC to detect beta blockers in concentrations
of nanogram and picogram. [-]
Description
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2019/2020
Type
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- Grau en Química [265]