Analysis of new psychoactive substances by atmospheric solids analysis probe tandem mass spectrometry
Visualitza/
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/158176
comunitat-uji-handle2:10234/71324
comunitat-uji-handle3:10234/98504
comunitat-uji-handle4:
TFG-TFMAquest recurs és restringit
Metadades
Títol
Analysis of new psychoactive substances by atmospheric solids analysis probe tandem mass spectrometryAutoria
Tutor/Supervisor; Universitat.Departament
Ibáñez Martínez, María; Sancho Llopis, Juan Vicente; Universitat Jaume I. Departament de Química Física i AnalíticaData de publicació
2020-06-26Editor
Universitat Jaume IResum
The growth in the demand for novel non-regulated substances, called new psychoactive
substances (NPS), is a concern among governments and society. These substances try to
mimic effects of the traditional illicit ... [+]
The growth in the demand for novel non-regulated substances, called new psychoactive
substances (NPS), is a concern among governments and society. These substances try to
mimic effects of the traditional illicit drugs such as cocaine, cannabis or heroin, for
example. They can be easily found through the Internet or physical stores, sold as “legal
highs” or “research chemicals”. People consume legal highs recreationally, even though
they do not know exactly their composition , which can cause a serious health problem.
Despite the different types of NPS, synthetic cathinones and synthetic cannabinoids are
the most popular based on seizures and number of identified compounds.
In this project, a novel methodology for NPS identification has been developed, using
tandem mass spectrometry equipped with atmospheric solids analysis probe, working in
the data-dependent acquisition mode. In the first step, a library containing fragmentation
spectra of 90 compounds was built. Then, in order to prove the applicability of the
methodology, blind samples were analysed, including powder, crystal and herbal blend
samples. Compound fragmentation spectra was obtained and searched for in the homemade spectral library, using for identification the MS Search option (within MassLynx
software). In addition, this method was applied for NPS detection in different surfaces,
such as the fingers of a person who had touched these products, using the same strategy
described above. The applicability and sensitivity of the methodology for this purpose
was tested.
NPS were correctly identified with this workflow based on the acquired fragmentation
spectra. The ASAP has proven to be a rapid technique for the suspect screening of NPS,
as no sample preparation or chromatographic separation are needed. [-]
Paraules clau / Matèries
Descripció
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2019/2020
Tipus de document
info:eu-repo/semantics/bachelorThesisDrets d'accés
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
Apareix a les col.leccions
- Grau en Química [265]