Mild maternal separation in mice of both sexes: impact in adultthood on vigor to approach or to escape motivational stimuli and interaction with dopamine depletion
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Mild maternal separation in mice of both sexes: impact in adultthood on vigor to approach or to escape motivational stimuli and interaction with dopamine depletionAutoria
Tutor/Supervisor; Universitat.Departament
Correa Sanz, María de las Mercedes; Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i Psicobiologia.Data de publicació
2020-07-21Editor
Universitat Jaume IResum
Early-life stress affects brain development and can lead to psychiatric disorders such as
depression later in life. Little is known about the effect of early-life stress on motivational
processes such as effort-based ... [+]
Early-life stress affects brain development and can lead to psychiatric disorders such as
depression later in life. Little is known about the effect of early-life stress on motivational
processes such as effort-based decision-making, which could be impaired in people with
depression. Mesolimbic dopamine (DA) regulates behavioral activation and effort in
motivated behaviors, and stress produces opposite effects on DA release depending if it is
acute or chronic. Maternal Separation (MS) could act as an early-life stressor depending on
its duration and intensity. Using CD1 male and female mice, we evaluate the impact of
early but mild MS (PND3-5, 90 min), on selection of effortful responses in adulthood under
positive or aversive conditions. In a three-choice-T-maze, mice preference for active
reinforcers such as a running wheel (RW) versus sedentary ones was evaluated, and in a
forced swim task (FST), time dedicated to escape or passively floating was measured. In
addition, we studied if MS interacts with DA depletion in adulthood, administering
tetrabenazine (TBZ), a VMAT-2 inhibitor that induces fatigue and anergia. Males and
females do not differ; they spend more time in the RW and less eating or sniffing a neutral
odor in the T-maze, independently of separation. However, separated mice of both sexes
spent more time in the RW, and climbing in the FST compared to non-separated mice. Only
among males, TBZ reduced time in RW, increased time eating, reduced climbing and
increased immobility. Females were not affected by DA depletion. Anxiety was evaluated
in a dark-light box, and separated males where less anxious than non-separated, but TBZ
did not affect either sex. [-]
Paraules clau / Matèries
Descripció
Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2019/2020.
Tipus de document
info:eu-repo/semantics/masterThesisDrets d'accés
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess