Mostrar el registro sencillo del ítem
Influence of calcium ion-modified implant surfaces in protein adsorption and implant integration
dc.contributor.author | Anitua, Eduardo | |
dc.contributor.author | Cerqueira, Andreia | |
dc.contributor.author | Romero-Gavilán, Francisco J | |
dc.contributor.author | García-Arnáez, Iñaki | |
dc.contributor.author | Martinez Ramos, Cristina | |
dc.contributor.author | Ozturan, Seda | |
dc.contributor.author | Azkagorta, Mikel | |
dc.contributor.author | Elortza, Felix | |
dc.contributor.author | GURRUCHAGA, MARILO | |
dc.contributor.author | Goñi, Isabel | |
dc.contributor.author | Suay, Julio | |
dc.contributor.author | Tejero, Ricardo | |
dc.date.accessioned | 2021-06-09T14:03:21Z | |
dc.date.available | 2021-06-09T14:03:21Z | |
dc.date.issued | 2021-04-21 | |
dc.identifier.citation | Anitua, E., Cerqueira, A., Romero-Gavilán, F. et al. Influence of calcium ion-modified implant surfaces in protein adsorption and implant integration. Int J Implant Dent 7, 32 (2021). https://doi.org/10.1186/s40729-021-00314-1 | ca_CA |
dc.identifier.issn | 2198-4034 | |
dc.identifier.uri | http://hdl.handle.net/10234/193369 | |
dc.description.abstract | Calcium (Ca) is a well-known element in bone metabolism and blood coagulation. Here, we investigate the link between the protein adsorption pattern and the in vivo responses of surfaces modified with calcium ions (Ca-ion) as compared to standard titanium implant surfaces (control). We used LC–MS/MS to identify the proteins adhered to the surfaces after incubation with human serum and performed bilateral surgeries in the medial section of the femoral condyles of 18 New Zealand white rabbits to test osseointegration at 2 and 8 weeks post-implantation (n=9). Results Ca-ion surfaces adsorbed 181.42 times more FA10 and 3.85 times less FA12 (p<0.001), which are factors of the common and the intrinsic coagulation pathways respectively. We also detected differences in A1AT, PLMN, FA12, KNG1, HEP2, LYSC, PIP, SAMP, VTNC, SAA4, and CFAH (p<0.01). At 2 and 8 weeks post-implantation, the mean bone implant contact (BIC) with Ca-ion surfaces was respectively 1.52 and 1.25 times higher, and the mean bone volume density (BVD) was respectively 1.35 and 1.13 times higher. Differences were statistically significant for BIC at 2 and 8 weeks and for BVD at 2 weeks (p<0.05). Conclusions The strong thrombogenic protein adsorption pattern at Ca-ion surfaces correlated with significantly higher levels of implant osseointegration. More effective implant surfaces combined with smaller implants enable less invasive surgeries, shorter healing times, and overall lower intervention costs, especially in cases of low quantity or quality of bone. | ca_CA |
dc.format.extent | 11 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Springer | ca_CA |
dc.relation | CIC bioGUNE | ca_CA |
dc.relation | ProteoRed-ISCIII | ca_CA |
dc.relation | CIBERehd Network and Severo Ochoa Grant | ca_CA |
dc.relation | Etortek and Elkartek programs | ca_CA |
dc.relation.isPartOf | International Journal of Implant Dentistry, Vol. 7, Article number: 32 (2021) | ca_CA |
dc.rights | © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | ca_CA |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | Titanium implants | ca_CA |
dc.subject | Osseointegration | ca_CA |
dc.subject | Blood coagulation | ca_CA |
dc.subject | Implant surface design | ca_CA |
dc.subject | Protein adsorption | ca_CA |
dc.title | Influence of calcium ion-modified implant surfaces in protein adsorption and implant integration | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1186/s40729-021-00314-1 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
project.funder.name | Generalitat Valenciana | ca_CA |
project.funder.name | Universidad del País Vasco | ca_CA |
project.funder.name | Gobierno Vasco | ca_CA |
oaire.awardNumber | POSDOC/2019/28 | ca_CA |
oaire.awardNumber | GRISOLIAP/2018/091 | ca_CA |
oaire.awardNumber | UFI11/56 | ca_CA |
oaire.awardNumber | PRE_2017_2_0044 | ca_CA |
oaire.awardNumber | PRB3 IPT17/0019 | ca_CA |
oaire.awardNumber | SEV-2016-0644 | ca_CA |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
ESID_Articles [477]
Excepto si se señala otra cosa, la licencia del ítem se describe como: © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License,
which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if
changes were made. The images or other third party material in this article are included in the article's Creative Commons
licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons
licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain
permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.