Mostrar el registro sencillo del ítem
Transfer hydrogenations catalyzed by streptavidin-hosted secondary amine organocatalysts
dc.contributor.author | Santi, Nicolò | |
dc.contributor.author | Morrill, Louis | |
dc.contributor.author | Świderek, Katarzyna | |
dc.contributor.author | Moliner, Vicent | |
dc.contributor.author | Luk, Louis Yu Pan | |
dc.date.accessioned | 2021-05-12T13:18:55Z | |
dc.date.available | 2021-05-12T13:18:55Z | |
dc.date.issued | 2021-02-21 | |
dc.identifier.citation | Santi, N., Morrill, L. C., Świderek, K., Moliner, V., & Luk, L. Y. (2021). Transfer hydrogenations catalyzed by streptavidin-hosted secondary amine organocatalysts. Chemical Communications, 57(15), 1919-1922. | ca_CA |
dc.identifier.issn | 1359-7345 | |
dc.identifier.issn | 1364-548X | |
dc.identifier.uri | http://hdl.handle.net/10234/193117 | |
dc.description.abstract | Here, the streptavidin–biotin technology was applied to enable organocatalytic transfer hydrogenation. By introducing a biotintethered pyrrolidine (1) to the tetrameric streptavidin (T-Sav), the resulting hybrid catalyst was able to mediate hydride transfer from dihydro-benzylnicotinamide (BNAH) to a,b-unsaturated aldehydes. Hydrogenation of cinnamaldehyde and some of its aryl-substituted analogues was found to be nearly quantitative. Kinetic measurements revealed that the T-Sav:1 assembly possesses enzyme-like behavior, whereas isotope effect analysis, performed by QM/MM simulations, illustrated that the step of hydride transfer is at least partially rate-limiting. These results have proven the concept that T-Sav can be used to host secondary amine-catalyzed transfer hydrogenations. | ca_CA |
dc.format.extent | 4 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Royal Society of Chemistry | ca_CA |
dc.relation.isPartOf | Chemical Communication, Vol. 57 (2021) | ca_CA |
dc.rights | This journal is © The Royal Society of Chemistry 2021 | ca_CA |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | streptavidin–biotin technology | ca_CA |
dc.subject | organocatalytic transfer hydrogenation | ca_CA |
dc.subject | amine-catalyzed transfer hydrogenations | ca_CA |
dc.title | Transfer hydrogenations catalyzed by streptavidin-hosted secondary amine organocatalysts | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1039/D0CC08142F | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://pubs.rsc.org/en/content/articlelanding/2021/cc/d0cc08142f#!divAbstract | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Cardiff School of Chemistry, Cardiff University | ca_CA |
project.funder.name | Royal Society | ca_CA |
project.funder.name | UK’s Wellcome Trust | ca_CA |
oaire.awardNumber | RPG-2017-195 | ca_CA |
oaire.awardNumber | RG150466 | ca_CA |
oaire.awardNumber | 202056/Z/16/Z | ca_CA |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
INAM_Articles [523]
-
QFA_Articles [825]
Articles de publicacions periòdiques