Exposure to per- and polyfluoroalkyl substances and premature skin aging
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Otros documentos de la autoría: Mousavi, Sayed Esmaeil; Delgado-Saborit, Juana Maria; Godderis, Lode
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INVESTIGACIONMetadatos
Título
Exposure to per- and polyfluoroalkyl substances and premature skin agingFecha de publicación
2020-10-24Editor
ElsevierISSN
0304-3894Cita bibliográfica
MOUSAVI, Sayed Esmaeil; DELGADO-SABORIT, Juana Maria; GODDERIS, Lode. Exposure to per-and polyfluoroalkyl substances and premature skin aging. Journal of Hazardous Materials, 2020, p. 124256.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/journal/journal-of-hazardous-materialsVersión
info:eu-repo/semantics/acceptedVersionPalabras clave / Materias
Resumen
Per- and polyfluoroalkyl substances (PFASs) are a ubiquitous group of persistent chemicals distributed globally in the environment. Skin aging is a notorious process that is prematurely induced by the interaction ... [+]
Per- and polyfluoroalkyl substances (PFASs) are a ubiquitous group of persistent chemicals distributed globally in the environment. Skin aging is a notorious process that is prematurely induced by the interaction between endogenous and exogenous factors, including exposure to environmental chemicals. The existing evidence suggests that skin absorption of PFASs through dermal contact may be an important route of exposure to these chemicals in humans. On the other hand, PFASs intake by other routes may lead to PFASs bioaccumulation in the skin via tissue bio-distribution. Additionally, the presence of PFASs in consumer and cosmetic products combined with their daily close contact with the skin could render humans readily susceptible to dermal absorption. Therefore, chronic low-dose dermal exposure to PFASs can occur in the human population, representing another important route of exposure to these chemicals. Studies indicate that PFASs can threaten skin health and contribute to premature skin aging. Initiation of inflammatory-oxidative cascades, induction of DNA damage such as telomere shortening, dysregulation of genes engaged in dermal barrier integrity and its functions, signaling of the mitogen activated protein kinase (MAPK) pathway, and last but not least the down-regulation of extracellular matrix (ECM) components are among the most likely mechanisms by which PFASs can contribute to premature skin aging. [-]
Publicado en
Journal of Hazardous Materials Volume 405 (2021), 124256Datos relacionados
https://doi.org/10.1016/j.jhazmat.2020.124256Derechos de acceso
0304-3894 © 2020 Elsevier B.V. All rights reserved
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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