Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory
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Title
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit MemoryAuthor (s)
Date
2021-03-18Publisher
Frontiers MediaISSN
1662-5129Bibliographic citation
Gil-Miravet I, Mañas-Ojeda A, Ros-Bernal F, Castillo-Gómez E, Albert-Gascó H, Gundlach AL and Olucha-Bordonau FE (2021) Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory. Front. Neuroanat. 15:637922. doi: 10.3389/fnana.2021.637922Type
info:eu-repo/semantics/articlePublisher version
https://www.frontiersin.org/articles/10.3389/fnana.2021.637922/fullVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Telencephalic cognitive and emotional circuits/functions are strongly modulated by
subcortical inputs. The main focus of past research on the nature of this modulation
has been on the widespread monoamine projections ... [+]
Telencephalic cognitive and emotional circuits/functions are strongly modulated by
subcortical inputs. The main focus of past research on the nature of this modulation
has been on the widespread monoamine projections to the telencephalon. However,
the nucleus incertus (NI) of the pontine tegmentum provides a strong GABAergic
and peptidergic innervation of the hippocampus, basal forebrain, amygdala, prefrontal
cortex, and related regions; and represents a parallel source of ascending modulation
of cognitive and emotional domains. NI GABAergic neurons express multiple peptides,
including neuromedin-B, cholecystokinin, and relaxin-3, and receptors for stress and
arousal transmitters, including corticotrophin-releasing factor and orexins/hypocretins. A
functional relationship exists between NI neurons and their associated peptides, relaxin-3
and neuromedin-B, and hippocampal theta rhythm, which in turn, has a key role in
the acquisition and extinction of declarative and emotional memories. Furthermore,
RXFP3, the cognate receptor for relaxin-3, is a Gi/o protein-coupled receptor, and its
activation inhibits the cellular accumulation of cAMP and induces phosphorylation of
ERK, processes associated with memory formation in the hippocampus and amygdala.
Therefore, this review summarizes the role of NI transmitter systems in relaying stressand arousal-related signals to the higher neural circuits and processes associated with
memory formation and retrieval. [-]
Is part of
Front. Neuroanat. 15:637922Funder Name
Fundación Alicia Koplowitz | Spanish Ministerio de Ciencia, Innovación y Universidades | Generalitat Valenciana | Universitat Jaume I | National Health and Medical Research Council of Australia
Project code
19I436 (FO-B, FR-B, EC-G, AM-O) | RTI2018-095698-B-I00 (FO-B, FR-B, EC-G, IG-M) | GV/2019/088 (EC-G) | UJI-B2019-54 (FO-B) and UJI-A2017-17 (FR-B) | 067522 (AG)
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