Prepulse Inhibition in Cocaine Addiction and Dual Pathologies
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INVESTIGACIONMetadata
Title
Prepulse Inhibition in Cocaine Addiction and Dual PathologiesAuthor (s)
Date
2021-02Publisher
MDPIISSN
https://doi.org/10.3390/brainsci11020269Bibliographic citation
Gil-Miravet, I.; Fuertes-Saiz, A.; Benito, A.; Almodóvar, I.; Ochoa, E.; Haro, G. Prepulse Inhibition in Cocaine Addiction and Dual Pathologies. Brain Sci. 2021, 11, 269. https://doi.org/10.3390/brainsci11020269Type
info:eu-repo/semantics/articlePublisher version
https://www.mdpi.com/2076-3425/11/2/269Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Cocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discr ... [+]
Cocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discriminating factor between these disorders. This work evaluated PPI and the phenotype of patients with cocaine-related disorder (CRD) who presented a dual diagnosis of schizophrenia or antisocial personality disorder. A total of 74 men aged 18–60 years were recruited for this research. The sample was divided into four groups: CRD (n = 14), CRD and schizophrenia (n = 21), CRD and antisocial personality disorder (n = 16), and a control group (n = 23). We evaluated the PPI and other possible vulnerability factors in these patients by using different assessment scales. PPI was higher in the CRD group at 30 ms (F(3, 64) = 2.972, p = 0.038). Three discriminant functions were obtained which allowed us to use the overall Hare Psychopathy Checklist Revised score, reward sensitivity, and PPI at 30 ms to predict inclusion of these patients in the different groups with a success rate of 79.7% (42.9% for CRD, 76.2% for CRD and schizophrenia, 100% for CRD and antisocial personality disorder, and 91.3% in the control group). Despite the differences we observed in PPI, this factor is of little use for discriminating between the different diagnostic groups and it acts more as a non-specific endophenotype in certain mental disorders, such as in patients with a dual diagnosis. [-]
Is part of
Brain Sciences, 2021, vol. 11, no 2Funder Name
Universidad CEU Cardenal Herrera | Ministerio de Economía, Industria y Competitividad | Instituto de Salud Carlos III | Fondo Europeo de Desarrollo Regional (FEDER) | Fundación del Hospital Provincial de Castellón
Project code
RD16/0017/0024 | CAF-20-026 | CAF-20-027
Project title or grant
Teaching + Research 2016 and Teaching + Research 2017 | Redes Temáticas de Investigación Cooperativa en Salud (RETICS), Red de Trastornos Adictivos, Complications of stimulant disorder
Rights
info:eu-repo/semantics/openAccess
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- MED_Articles [662]
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