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Postoperative intestinal fistula in primary advanced ovarian cancer surgery
dc.contributor.author | Llueca, Antoni | |
dc.contributor.author | Serra Rubert, Anna | |
dc.contributor.author | CLIMENT MARTÍ, MARIA TERESA | |
dc.contributor.author | Maiocchi, Karina | |
dc.contributor.author | Villarín, Álvaro | |
dc.contributor.author | Delgado Barriga, Katty | |
dc.contributor.author | Marí-Alexandre, Josep | |
dc.contributor.author | Gilabert-Estellés, Juan | |
dc.contributor.author | Carrasco, Paula | |
dc.contributor.author | Segarra vidal , Blanca | |
dc.contributor.author | GOMEZ QUILES, LUIS | |
dc.contributor.author | Hidalgo Mora, Juan José | |
dc.contributor.author | Escrig-Sos, Javier | |
dc.contributor.author | Laguna Sastre, José Manuel | |
dc.date.accessioned | 2021-03-05T12:02:15Z | |
dc.date.available | 2021-03-05T12:02:15Z | |
dc.date.issued | 2021-01-06 | |
dc.identifier.citation | Llueca A, Serra A, Climent MT, Maiocchi K, Villarin A, Delgado K, Mari-Alexandre J, Gilabert-Estelles J, Carrasco P, Segarra B, Gomez L, Hidalgo JJ, Escrig J, Laguna M. Postoperative Intestinal Fistula in Primary Advanced Ovarian Cancer Surgery. Cancer Manag Res. 2021;13:13-23 https://doi.org/10.2147/CMAR.S280511 | ca_CA |
dc.identifier.issn | 1179-1322 | |
dc.identifier.uri | http://hdl.handle.net/10234/192477 | |
dc.description.abstract | Background: Advanced ovarian cancer (AOC) requires an aggressive surgery with large visceral resections in order to achieve an optimal or complete cytoreduction and increase the patient’s survival. However, the surgical aggressiveness in the treatment of AOC is not exempt from major complications, such as the gastrointestinal fistula (GIF), which stands out among others due to its high morbidity and mortality. Methods: We evaluated the clinicopathological features in patients with AOC and their association with GI. Data for 107 patients with AOC who underwent primary debulking surgery were analyzed retrospectively. Clinicopathological features, including demographic, surgical procedures and follow-up data, were analyzed in relation to GIF. Results: GIF was present in 11% of patients in the study, 5 (4.5%) and 7 (6.4%) of colorectal and small bowel origin, respectively. GIF was significantly associated with peritoneal cancer index (PCI) > 20, more than 2 visceral resections, and multiple digestive resections. Overall and disease-free survival were also associated with GIF. Multivariate analysis identified partial bowel obstruction and operative bleeding as independent prognostic factors for survival. The presence of GIF is positively associated with poor prognosis in patients with AOC. Conclusion: Given the importance of successful cytoreductive surgery in AOC, the assessment of the amount of tumor and the aggressiveness of the surgery to avoid the occurrence of GIF become a priority in patients with AOC. | ca_CA |
dc.format.extent | 11 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Dove Medical Press | ca_CA |
dc.relation.isPartOf | Cancer Management and Research, vol.13 (2021) | ca_CA |
dc.rights | (c) 2021 Llueca et al. | ca_CA |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | advanced ovarian cancer surgery | ca_CA |
dc.subject | complications | ca_CA |
dc.subject | intestinal leakage | ca_CA |
dc.subject | intestinal fistula | ca_CA |
dc.title | Postoperative intestinal fistula in primary advanced ovarian cancer surgery | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.2147/CMAR.S280511 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.dovepress.com/postoperative-intestinal-fistula-in-primary-advanced-ovarian-cancer-su-peer-reviewed-article-CMAR# | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Instituto de Salud Carlos III (ISCIII) | ca_CA |
oaire.awardNumber | PI17/01945 | ca_CA |
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