Environmentally relevant iron oxide nanoparticles produce limited acute pulmonary effects in rats at realistic exposure levels
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INVESTIGACIONMetadatos
Título
Environmentally relevant iron oxide nanoparticles produce limited acute pulmonary effects in rats at realistic exposure levelsAutoría
Fecha de publicación
2021-01-08Editor
MDPIISSN
1422-0067Cita bibliográfica
Guo, C.; Weber, R.J.M.; Buckley, A.; Mazzolini, J.; Robertson, S.; Delgado-Saborit, J.M.; Rappoport, J.Z.; Warren, J.; Hodgson, A.; Sanderson, P.; et al. Environmentally Relevant Iron Oxide Nanoparticles Produce Limited Acute Pulmonary Effects in Rats at Realistic Exposure Levels. Int. J. Mol. Sci. 2021, 22, 556. https://doi.org/10.3390/ijms22020556Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.mdpi.com/1422-0067/22/2/556/htmVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Iron is typically the dominant metal in the ultrafine fraction of airborne particulate matter.
Various studies have investigated the toxicity of inhaled nano-sized iron oxide particles (FeOxNPs)
but their results ... [+]
Iron is typically the dominant metal in the ultrafine fraction of airborne particulate matter.
Various studies have investigated the toxicity of inhaled nano-sized iron oxide particles (FeOxNPs)
but their results have been contradictory, with some indicating no or minor effects and others finding
effects including oxidative stress and inflammation. Most studies, however, did not use materials
reflecting the characteristics of FeOxNPs present in the environment. We, therefore, analysed the
potential toxicity of FeOxNPs of different forms (Fe3O4
, α-Fe2O3 and γ-Fe2O3
) reflecting the characteristics of high iron content nano-sized particles sampled from the environment, both individually
and in a mixture (FeOx-mix). A preliminary in vitro study indicated Fe3O4 and FeOx-mix were more
cytotoxic than either form of Fe2O3
in human bronchial epithelial cells (BEAS-2B). Follow-up in vitro
(0.003, 0.03, 0.3 µg/mL, 24 h) and in vivo (Sprague–Dawley rats, nose-only exposure, 50 µg/m3 and
500 µg/m3
, 3 h/d × 3 d) studies therefore focused on these materials. Experiments in vitro explored
responses at the molecular level via multi-omics analyses at concentrations below those at which
significant cytotoxicity was evident to avoid detection of responses secondary to toxicity. Inhalation
experiments used aerosol concentrations chosen to produce similar levels of particle deposition
on the airway surface as were delivered in vitro. These were markedly higher than environmental
concentrations. No clinical signs of toxicity were seen nor effects on BALF cell counts or LDH
levels. There were also no significant changes in transcriptomic or metabolomic responses in lung or
BEAS-2B cells to suggest adverse effects. [-]
Publicado en
International Journal of Molecular Sciences. Vol. 22, issue 2, nº 556 (January-2 2021)Entidad financiadora
UK’s Natural Environment Research Council | Medical Research Council
Código del proyecto o subvención
NE/I008314
Título del proyecto o subvención
FABLE project
Derechos de acceso
info:eu-repo/semantics/openAccess
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- MED_Articles [657]
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