Photodynamic Inactivation of Staphylococcus aureus Biofilms Using a Hexanuclear Molybdenum Complex Embedded in Transparent polyHEMA Hydrogels
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Título
Photodynamic Inactivation of Staphylococcus aureus Biofilms Using a Hexanuclear Molybdenum Complex Embedded in Transparent polyHEMA HydrogelsAutoría
Fecha de publicación
2020Editor
American Chemical SocietyISSN
2373-9878Cita bibliográfica
Noelia López-López, Ignacio Muñoz Resta, Rosa de Llanos, Juan F. Miravet, Maxim Mikhaylov, Maxim N. Sokolov, Sofía Ballesta, Isabel García-Luque, and Francisco Galindo. Photodynamic Inactivation of Staphylococcus aureus Biofilms Using a Hexanuclear Molybdenum Complex Embedded in Transparent polyHEMA Hydrogels. ACS Biomaterials Science & Engineering 2020 6 (12), 6995-7003 DOI: 10.1021/acsbiomaterials.0c00992Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://pubs.acs.org/doi/full/10.1021/acsbiomaterials.0c00992Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
Three new photoactive polymeric materials embedding a hexanuclear molybdenum cluster (Bu4N)2[Mo6I8(CH3COO)6] (1) have been synthesized and characterized by means of Fourier-transform infrared spectroscopy (FTIR), ... [+]
Three new photoactive polymeric materials embedding a hexanuclear molybdenum cluster (Bu4N)2[Mo6I8(CH3COO)6] (1) have been synthesized and characterized by means of Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and emission spectroscopy. The materials are obtained in the format of transparent and thin sheets, and the formulations used to synthesize them are comprised of 2-hydroxyethyl methacrylate (HEMA), as a polymerizable monomer, and ethylene glycol dimethacrylate (EGDMA) or poly(ethylene glycol)dimethacrylate (PEGDMA), as cross-linkers. All the polymeric hydrogels generate singlet oxygen (1O2) upon irradiation with visible light (400–700 nm), as demonstrated by the reactivity toward two chemical traps of this reactive species (9,10-dimethylanthracene and 1,5-dihydroxynaphthalene). Some differences have been detected between the photoactive materials, probably attributable to variations in the permeability to solvent and oxygen. Notably, one of the materials resisted up to 10 cycles of photocatalytic oxygenation reactions of 1,5-dihydroxynaphthalene. All three of the polyHEMA hydrogels doped with 1 are efficient against S. aureus biofilms when irradiated with blue light (460 nm). The material made with the composition of 90% HEMA and 10% PEGDMA (Mo6@polymer-III) is especially easy to handle, because of its flexibility, and it achieves a notable level of bacterial population reduction (3.0 log10 CFU/cm2). The embedding of 1 in cross-linked polyHEMA sheets affords a protective environment to the photosensitizer against aqueous degradation while preserving the photochemical and photobactericidal activity. [-]
Publicado en
ACS Biomaterials Science and Engineering, 2020, vol. 6, no 12Entidad financiadora
Ministerio de Ciencia, Innovacion y Universidades of Spain: RTI2018-101675-B-I00; Universitat Jaume I: UJI-B2018-30; Plan Nacional de I +D+ i 2013-2016; Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Ciencia, Innovacion y Universidades, Spanish Network for Research in Infectious Diseases: REIPI RD16/0016/0001; Generalitat Valenciana: GRISOLIAP/2018/071; Ministerio de Educacion y Formacion Profesional, Spanish Government
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Copyright © American Chemical Society
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http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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