Chromatography hyphenated to high resolution mass spectrometry in untargeted metabolomics for investigation of food (bio)markers
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Other documents of the author: Lacalle-Bergeron, Leticia; Izquierdo-Sandoval, David; Sancho, Juan V; López, Francisco; Hernandez, Felix; Portoles, Tania
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Title
Chromatography hyphenated to high resolution mass spectrometry in untargeted metabolomics for investigation of food (bio)markersAuthor (s)
Date
2021-02-01Publisher
ElsevierISSN
0165-9936Bibliographic citation
LACALLE-BERGERON, Leticia, et al. Chromatography hyphenated to high resolution mass spectrometry in untargeted metabolomics for investigation of food (bio) markers. TrAC Trends in Analytical Chemistry, 2021, p. 116161.Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S0165993620303903?dgcid=rss_sd_allVersion
info:eu-repo/semantics/acceptedVersionSubject
Abstract
Currently, there is a growing demand by our society, authorities and science to increase the
knowledge about the quality of food and its relationship with health and disease. Untargeted
metabolomics approaches are ... [+]
Currently, there is a growing demand by our society, authorities and science to increase the
knowledge about the quality of food and its relationship with health and disease. Untargeted
metabolomics approaches are emerging as powerful tools for exploring metabolic changes in
biological systems under different conditions with great potential in the food field. To this aim, it
is necessary to apply advanced analytical techniques, such as chromatography hyphenated to high
resolution mass spectrometry, which provides enough sensitivity and selectivity to cover a wide
range of metabolites in complex samples, as food and biological samples. The objective of this
work is to provide an overview of the most widely adopted strategies based on the use of high
resolution mass spectrometry-based techniques for the identification of food (bio)markers through
the untargeted metabolomics workflow. Detailed information is provided about the trends in each
stage of the metabolomics process from updated literature with the objective to help researchers
to select the most appropriate metabolic approaches. [-]
Is part of
TrAC Trends in Analytical Chemistry, 2020, p. 116161Investigation project
L Lacalle-Bergeron acknowledges the financial support of Universitat Jaume I, Spain for his pre-doctoral grant (UJI 19I001/03). T. Portolés acknowledges Ramon y Cajal Program from the Ministry of Economy and Competitiveness of Spain (RYC-2017-22525) for funding her research. D. Izquierdo-Sandoval acknowledges the Ministry of Science, Innovation and Universities of Spain for funding his research through the FPU pre-doctoral program (FPU19/01839). The authors acknowledge the financial support of Universitat Jaume I (UJI-B2020-37) and Generalitat Valenciana, as research group of excellence PROMETEO/2019/040.Rights
info:eu-repo/semantics/openAccess
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